细胞焦亡:连接肠道菌群与肝脏疾病的新桥梁  

Pyroptosis:A new bridge connecting gut microbiota and liver diseases

作　　者：赵奕杰 谢露 张亚亭 刘光伟[2] ZHAO Yijie;XIE Lu;ZHANG Yating;LIU Guangwei(The First Clinical Medical College of Henan University of Chinese Medicine,Zhengzhou 450000,China;Spleen,Stomach and Hepatobiliary Department,The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,China)

机构地区：[1]河南中医药大学第一临床医学院,郑州450000 [2]河南中医药大学第一附属医院脾胃肝胆科,郑州450000

出　　处：《临床肝胆病杂志》2024年第9期1908-1915,共8页Journal of Clinical Hepatology

基　　金：河南省自然科学基金(222300420490);河南省科技研发计划联合基金(222301420069);河南省特色骨干学科中医学学科建设项目(STG-ZYXKY-2020017)。

摘　　要：自肠-肝轴的概念被提出以来,已有大量研究着眼于探索肠道菌群和肝病之间的联系,但以细胞焦亡为枢纽,探究肠-肝串扰的内在机制的观点仍处于萌芽阶段。本文主要通过叙述了肠道菌群失调通过影响黏膜屏障的完整性和胆汁酸的代谢,诱导细胞焦亡,进而影响肝脏相关疾病的发生和进展的过程,并总结出肠道菌群失调通过诱导NLRP3/AIM2/Caspase-1依赖型、Caspase-4/11/GSDMD依赖型和Caspase-3/GSDME依赖型细胞焦亡以影响肝脏相关疾病的观点。希望通过建立细胞焦亡与肠-肝免疫串扰之间的联系,为未来肝病的诊治提供新的思路和靶点。Since the proposal of the concept of the gut-liver axis,a large number of studies have focused on exploring the connection between gut microbiota and liver disease;however,the idea of using pyroptosis as a hub to explore the intrinsic mechanism of gut-liver crosstalk is still in its infancy.This article mainly describes the process by which gut microbiota dysbiosis affects the integrity of mucosal barrier and bile acid metabolism,induces pyroptosis,and thereby affects the development and progression of liver diseases,and it also concludes that gut microbiota dysbiosis affects liver diseases by inducing NLRP3/AIM2/Caspase-1-dependent,Caspase-4/11/GSDMD-dependent,and Caspase-3/GSDME-dependent pyroptosis.In summary,this study aims to provide new ideas and targets for the future diagnosis and treatment of liver diseases by establishing the connection between pyroptosis and intestinal-liver immune crosstalk.

关 键 词：肝疾病 胃肠道微生物组 细胞焦亡 胆汁酸类和盐类 

分 类 号：R575[医药卫生—消化系统]