巨噬细胞在原发性胆汁性胆管炎发生发展中的作用  

Role of macrophages in the development and progression of primary biliary cholangitis

作　　者：邓宗柒 邰文琳[1] DENG Zongqi;TAI Wenlin(Department of Clinical Laboratory,The Second Affiliated Hospital of Kunming Medical University,Kunming 650101,China)

机构地区：[1]昆明医科大学第二附属医院检验科,昆明650101

出　　处：《临床肝胆病杂志》2024年第9期1924-1928,共5页Journal of Clinical Hepatology

基　　金：国家自然科学基金(82060385);昆明医科大学2024年研究生创新基金(2024S091)。

摘　　要：原发性胆汁性胆管炎(PBC)是一种持续的炎症性自身免疫性肝病,以肝内小胆管炎症损伤和胆汁淤积为主要特征。目前,PBC的确切发病机制尚不清楚,但一致认为PBC是多种因素协同作用的结果。而在与PBC相关的免疫和炎症级联反应中,巨噬细胞作为必不可少的免疫细胞出现,积极参与对胆管上皮细胞的损伤。本文介绍了巨噬细胞在PBC中的来源定位及异质性变化,综述了巨噬细胞在PBC发病机制中的潜在作用。Primary biliary cholangitis(PBC)is a persistent inflammatory autoimmune liver disease characterized by inflammatory injury and cholestasis in the small intrahepatic bile ducts.At present,the exact pathogenesis of PBC remains unknown,but a consensus has been reached on the fact that PBC is the result of the synergistic effect of various factors.In the cascade of immune and inflammatory reactions associated with PBC,macrophages appear as essential immune cells and actively participate in the damage to bile duct epithelial cells.This article introduces the origin and heterogeneity of macrophages in PBC and reviews the potential role of macrophages in the pathogenesis of PBC.

关 键 词：原发性胆汁性胆管炎 单核细胞 巨噬细胞 病理过程 

分 类 号：R575.7[医药卫生—消化系统]