氧感知机制在乳腺癌中的研究进展及其临床应用前景  

Research progress and clinical application prospect of oxygen sensing mechanism in breast cancer

作　　者：熊晶晶 耿祖涵 房文通[3] 张静[1] XIONG Jingjing;GENG Zuhan;FANG Wentong;ZHANG Jing(Institute of Medical Sciences,Zhongnan Hospital of Wuhan University,Wuhan 430071,Hubei Province,China;Union Hospital Affiliated to Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430021,Hubei Province,China;Department of Pharmacy,Jiangsu Provincial People's Hospital,Nanjing 210029,Jiangsu Province,China)

机构地区：[1]武汉大学中南医院医学研究院,湖北武汉430071 [2]华中科技大学同济医学院附属协和医院,湖北武汉430021 [3]江苏省人民医院药学部,江苏南京210029

出　　处：《世界临床药物》2024年第8期809-813,共5页World Clinical Drug

基　　金：国家自然科学基金面上项目(32370762);国家重点研发计划青年科学家项目(2022YFA1305400);中国药学会医院药学专业委员会科研专项资助项目重点项目CPA-Z05-ZC-2022-002。

摘　　要：乳腺癌(breast cancer)是常见恶性肿瘤之一,严重威胁女性健康。乳腺癌作为一种实体肿瘤,由于微血管系统的结构和功能异常会产生缺氧区域。缺氧通常与更具侵袭性的表型、转移风险增加和肿瘤治疗的耐药性成正相关。该文从不同类型的α-酮戊二酸依赖型双加氧酶介导的乳腺癌氧感知机制以及其临床应用前景作归纳总结,以加深人们对乳腺癌氧感知机制及其作用的认识。Breast cancer is one of the common malignant tumors,which seriously threatens women's health.As a kind of solid tumor,breast cancer can produce hypoxic areas due to the abnormal structure and function of the microvascular system.Hypoxia is generally positively associated with a more aggressive phenotype,increased risk of metastasis,and resistance to tumor therapy.In this paper,the oxygen sensing mechanisms mediated by different types of-ketoglutaratedependent dioxygenase in breast cancer and their clinical application prospects were summarized,in order to deepen the understanding of oxygen sensing mechanisms and functions in breast cancer.

关 键 词：乳腺癌 α-酮戊二酸依赖型双加氧酶 氧感知机制 临床应用前景 

分 类 号：R737.9[医药卫生—肿瘤]