5-甲基胞嘧啶甲基化修饰对肿瘤调控作用及其研究进展  

Research progress of 5-methylcytosine methylation on tumor regulation

作　　者：徐高姌 吴梓芳 范亚楠 江明[1] 胡汉昆[4] XU Gaoran#;WU Zifang;FAN Ya'nan;JIANG Ming;HU Hankun(Department of Thyroid and Breast Surgery,Wuhan Central Hospital,Wuhan 430022,Hubei Province,China;Department of Ultrasound,Wuhan University Hospital,Wuhan 430062,Hubei Province,China;Department of Thyroid and Breast Surgery,Ezhou Central Hospital,Ezhou 436000,Hubei Province,China;Department of Pharmacy,Zhongnan Hospital of Wuhan University,Wuhan 430071,Hubei Province,China)

机构地区：[1]武汉市中心医院甲状腺乳腺外科,湖北武汉430022 [2]武汉大学校医院超声科,湖北武汉430062 [3]鄂州市中心医院甲状腺乳腺外科,湖北鄂州436000 [4]武汉大学中南医院药学部,湖北武汉430071

出　　处：《世界临床药物》2024年第8期814-820,共7页World Clinical Drug

基　　金：中国药学会医院药学专业委员会重点科研项目(CPA-Z05-ZC-2022-002)。

摘　　要：5-甲基胞嘧啶(5-methylcytosine,m5C)甲基化修饰是RNA转录后修饰的重要表观遗传学调控方式。证据表明,m5C甲基化修饰可调节RNA的稳定性、翻译、转录、核输出以及裂解等细胞功能,以此介导细胞的增殖、分化、凋亡及应激反应等生物功能。m5C甲基化修饰过程由m5C甲基转移酶、m5C去甲基转移酶和m5C甲基结合酶催化调控。多种甲基化修饰酶的异常表达在各种恶性肿瘤中被发现,并被用来预测患者预后。该文就m5C甲基化修饰对肿瘤调控作用作综述,并对其相关研究的前景进行讨论。5-methylcytosine(m5C)methylation is an important epigenetic regulation of RNA post-transcriptional modification.Evidence suggests that m5C methylation can regulate RNA stability,translation,transcription,nuclear output and cleavage,thereby mediating cell proliferation,differentiation,apoptosis,stress response and other biological functions.The m5C methylation modiffcation process is catalyzed by m5C methyltransferase,m5C demethyltransferase and m5C methylbinding enzyme.Abnormal expression of multiple methylation modifying enzymes has been found in various cancers and is used to predict patients'outcomes.This paper reviewed the regulatory effects of m5C methylation modiffcation on tumors,and discussed the prospect of related research.

关 键 词：5-甲基胞嘧啶甲基化 肿瘤 甲基化修饰酶 

分 类 号：R730[医药卫生—肿瘤]