改良卵巢移位术对晚期宫颈癌患者性激素及肿瘤标志物水平的影响  

Effect of modified ovarian transposition on sex hormone and tumor marker levels in patients with advanced cervical cancer

作　　者：赵梦丹 陈秋丹 陆俊杰 叶施雨 ZHAO Mengdan;CHEN Qiudan;LU Junjie;YE Shiyu(Department of Clinical Laboratory,Jing’an Branch of Huashan Hospital Affiliated to Fudan University/Shanghai Jing’an District Central Hospital,Shanghai 200040,China)

机构地区：[1]复旦大学附属华山医院静安分院/上海市静安区中心医院检验科,上海2000400

出　　处：《癌症进展》2024年第15期1655-1658,共4页Oncology Progress

基　　金：上海市卫生健康委员会科研项目(202140240)。

摘　　要：目的 探讨改良卵巢移位术对晚期宫颈癌患者性激素及肿瘤标志物水平的影响。方法 根据手术方法的不同将166例晚期宫颈癌患者分为对照组(n=75,腹膜外卵巢移位术)和观察组(n=91,改良卵巢移位术)。比较两组患者的手术相关指标、性激素[孕酮(P)、雌二醇(E2)、卵泡刺激素(FSH)、睾酮(T)、黄体生成素(LH)、催乳素(PRL)]水平、肿瘤标志物[癌胚抗原(CEA)、鳞状细胞癌抗原(SCC-Ag)、糖类抗原50(CA50)]水平及并发症发生情况。结果 观察组患者术中出血量明显少于对照组,手术时间、术后首次排气时间及住院时间均明显短于对照组,差异均有统计学意义(P﹤0.01)。治疗前和治疗后,两组患者P、E2、FSH、T、LH、PRL水平比较,差异均无统计学意义(P﹥0.05)。治疗后,两组患者CEA、SCC-Ag、CA50水平均低于本组治疗前,观察组患者CEA、SCC-Ag、CA50水平均低于对照组,差异均有统计学意义(P﹤0.05)。观察组患者的并发症总发生率低于对照组,差异有统计学意义(P﹤0.05)。结论 改良卵巢移位术治疗晚期宫颈癌患者能够降低肿瘤标志物水平,稳定性激素水平,促进患者术后恢复,降低并发症发生率。Objective To explore the effect of modified ovarian transposition on sex hormone and tumor marker lev-els in patients with advanced cervical cancer.Method A total of 166 patients with advanced cervical cancer were divid-ed into control group(n=75,extraperitoneal ovarian transposition)and observation group(n=91,modified ovarian trans-position)according to different surgical methods.The surgery-related indexes,sex hormones[progesterone(P),estradiol(E2),follicle stimulating hormone(FSH),testosterone(T),luteinizing hormone(LH),prolactin(PRL)]levels,tumor mark-ers[carcinoembryonic antigen(CEA),squamous cell carcinoma antigen(SCC-Ag),carbohydrate antigen 50(CA50)]lev-els,and the incidence of complications were compared between the two groups.Result The intraoperative blood loss in the observation group was significantly less than that in the control group,and the operation time,postoperative first ex-haust time and hospital stay were significantly shorter than those in the control group,and the differences were statistical-ly significant(P<0.01).Before and after treatment,there were no significant differences in P,E2,FSH,T,LH and PRL lev-els between the two groups(P>0.05).After treatment,the CEA,SCC-Ag and CA50 levels in both groups were lower than those before treatment,and the CEA,SCC-Ag and CA50 levels in observation group were lower than those in control group,and the differences were statistically significant(P<0.05).The total incidence of complications in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Modified ovarian transposition can reduce the levels of tumor markers in the treatment of advanced cervical cancer pa-tients,stabilize the levels of sex hormones,promote the postoperative recovery,and reduce the incidence of complications.

关 键 词：改良卵巢移位术 晚期宫颈癌 性激素 肿瘤标志物 

分 类 号：R737.33[医药卫生—肿瘤]