不同营养支持方式对鼻咽癌放疗患者胃肠道功能及生活质量的影响  

Effects of different nutritional support methods on gastrointestinal function and quality of life in patients with nasopharyngeal carcinoma undergoing radiotherapy

作　　者：张屹冰 邢媛媛[1] 张莉[1] 苏丹[1] ZHANG Yibing;XING Yuanyuan;ZHANG Li;SU Dan(Department of Rhinology(2),the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,He’nan,China)

机构地区：[1]郑州大学第一附属医院鼻科(2),郑州4500000

出　　处：《癌症进展》2024年第15期1714-1718,共5页Oncology Progress

摘　　要：目的 探讨肠内营养支持和肠外营养支持对鼻咽癌放疗患者胃肠道功能及生活质量的影响。方法依据营养支持方式的不同将76例鼻咽癌放疗患者分为肠内营养组(n=37)和肠外营养组(n=39)。所有患者均采用相同的放疗方案、放疗时间及常规干预,肠内营养组患者给予经鼻胃管肠内营养支持,肠外营养组患者给予肠外营养支持。比较两组患者的胃肠道功能指标[脂多糖(LPS)、二胺氧化酶(DAO)、D-乳酸、乳果糖/甘露醇(L/M)]、生活质量(生活质量评价量表)、负性情绪[汉密尔顿焦虑量表(HAMA)和汉密尔顿抑郁量表(HAMD)]、临床疗效及不良反应发生情况。结果 干预后,两组患者LPS、DAO、D-乳酸、L/M均高于本组干预前,肠外营养组患者LPS、DAO、D-乳酸、L/M均高于肠内营养组,差异均有统计学意义(P﹤0.05)。干预后,两组患者心理功能、躯体功能、社会功能、物质生活状态评分均高于本组干预前,肠外营养组患者心理功能、躯体功能、社会功能、物质生活状态评分均高于肠内营养组,差异均有统计学意义(P﹤0.05)。干预后,两组患者HAMA、HAMD评分均低于本组干预前,肠外营养组患者HAMA、HAMD评分均低于肠内营养组,差异均有统计学意义(P﹤0.05)。肠内营养组患者的总有效率高于肠外营养组(P﹤0.05)。肠外营养组患者恶心呕吐发生率高于肠内营养组,吞咽痛发生率低于肠内营养组,差异均有统计学意义(P﹤0.05)。结论 对于鼻咽癌放疗患者,肠内营养支持有助于胃肠道功能恢复,提高临床疗效,降低恶心呕吐发生率,而肠外营养支持有助于改善生活质量和负性情绪,降低吞咽痛发生率。Objective To investigate the effects of enteral nutrition support and parenteral nutrition support on gastro-intestinal function and quality of life in patients with nasopharyngeal carcinoma undergoing radiotherapy.Method Ac-cording to different nutritional support methods,76 patients with nasopharyngeal carcinoma who underwent radiotherapy were divided into enteral nutrition group(n=37)and parenteral nutrition group(n=39).All patients were treated with the same radiotherapy regimen,radiotherapy duration and routine intervention.Patients in enteral nutrition group were given enteral nutrition support with nasogastric tube,and patients in parenteral nutrition group were given parenteral nutrition support.The gastrointestinal function indexes[lipopolysaccharide(LPS),diamine oxidase(DAO),D-lactic acid,lactulose/mannitol(L/M)],quality of life(quality of life scale),negative emotions[Hamilton anxiety scale(HAMA)and Hamilton depression scale(HAMD)],clinical efficacy and occurrence of adverse reactions were compared between the two groups.Result After intervention,the LPS,DAO,D-lactic acid and L/M in both groups were higher than those before interven-tion,and the LPS,DAO,D-lactic acid and L/M in parenteral nutrition group were higher than those in enteral nutrition group,and the differences were statistically significant(P<0.05).After intervention,the scores of mental function,physi-cal function,social function and material life status in both groups were higher than those before intervention,the scores of mental function,physical function,social function and material life status in parenteral nutrition group were higher than those in enteral nutrition group,and the differences were statistically significant(P<0.05).After intervention,the HAMA and HAMD scores in both groups were lower than those before intervention,and the HAMA and HAMD scores in parenteral nutrition group were lower than those in enteral nutrition group,and the differences were statistically signifi-cant(P<0.05).The total effective rate of enteral nutr

关 键 词：肠内营养支持 肠外营养支持 疗效 胃肠道功能 生活质量 

分 类 号：R739.62[医药卫生—肿瘤]