阿立哌唑对男性首发精神分裂症患者性激素、心肌酶谱及勃起功能的影响  

Effect of aripiprazole on sex hormones,myocardial enzymes and erectile function in male patients with first-episode schizophrenia

作　　者：尹杰 赵天真 庞堃[2] 赵晓彦 YIN Jie;ZHAO Tian-zhen;PANG Kun(Department of Pharmacy,Qinhuangdao Jiulongshan Hospital,Qinhuangdao Hebei 066000,China;Department of Psychiatry,Qinhuangdao Jiulongshan Hospital,Qinhuangdao Hebei 066000,China)

机构地区：[1]秦皇岛市九龙山医院药剂科,河北秦皇岛066000 [2]秦皇岛市九龙山医院精神科,河北秦皇岛066000 [3]北京市回龙观医院药物临床试验机构,北京100096

出　　处：《临床和实验医学杂志》2024年第15期1610-1614,共5页Journal of Clinical and Experimental Medicine

基　　金：河北省卫生健康委科研基金项目(编号:20211460)。

摘　　要：目的分析阿立哌唑对男性首发精神分裂症(SCH)患者性激素、心肌酶谱及勃起功能的影响。方法回顾性收集2023年1月至2024年1月秦皇岛市九龙山医院收治的120例男性首发SCH患者的临床资料。根据治疗方法不同分为利培酮组(n=60)、阿立哌唑组(n=60)。利培酮组患者口服利培酮,初始给药量1 mg/d,1~2周给药剂量逐渐增加至6 mg/d,1次/d。阿立哌唑组患者口服阿立哌唑,初始给药量5 mg/d,治疗2~3周剂量增加至30 mg/d,1次/d。比较两组疗效,对比两组治疗前和治疗2个月后空腹血糖、总胆固醇、甘油三酯、性激素(睾酮、雌二醇、黄体生成素)、心肌酶[肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、乳酸脱氢酶(LDH)]变化、国际勃起功能指数-5问卷(IIEF-5)评分变化,比较两组药物不良反应发生情况。结果治疗2个月后,两组睾酮、雌二醇、黄体生成素水平均较治疗前明显升高,阿立哌唑组的睾酮、雌二醇、黄体生成素水平分别为(4.89±0.47)ng/mL、(36.27±3.74)ng/mL、(6.21±0.68)mU/mL,均明显高于利培酮组[(4.05±0.41)ng/mL、(32.22±3.36)ng/mL、(5.11±0.52)mU/mL],差异均有统计学意义(P<0.05)。治疗2个月后,两组CK、CK-MB、LDH水平均较治疗前明显降低,阿立哌唑组CK、CK-MB、LDH水平分别为(111.34±11.23)、(19.24±1.95)、(147.66±15.24)U/L,均明显高于利培酮组[(101.22±10.56)、(16.32±1.85)、(121.85±13.26)U/L],差异均有统计学意义(P<0.05)。治疗2个月后,利培酮组的性信心、性驱动、性高潮满意度、性唤起、阴茎勃起能力评分均较治疗前明显降低,阿立哌唑组性信心、性驱动、性高潮满意度、性唤起、阴茎勃起能力评分分别为(3.75±0.38)、(3.93±0.39)、(3.85±0.38)、(4.08±0.41)、(3.97±0.40)分,均明显高于利培酮组[(2.29±0.22)、(2.41±0.25)、(2.07±0.19)、(2.71±0.28)、(2.20±0.22)分],差异均有统计学意义(P<0.05)。结论阿立哌唑对男性首发SCH患者疗效明确,有效调节Objective To analyze the effect of aripiprazole on sex hormones,myocardial enzymes and erectile function in male patients with first-episode schizophrenia(SCH).Methods The clinical data of 120 male patients with first-episode SCH admitted to Qinhuangdao Jiulongshan Hospital from January 2023 to January 2024 were collected retrospectively.According to different treatment methods,the patients were divided into the risperidone group(n=60)and the aripiprazole group(n=60).The risperidone group received oral administration of risperidone at an initial dose of 1 mg/d,and the dose was gradually increased to 6 mg/d after 1-2 weeks of treatment,1 time/d.The aripiprazole group received oral administration of aripiprazole at an initial dose of 5 mg/d,and the dose was increased to 30 mg/d after 2-3 weeks of treatment,1 time/d.The efficacy,the changes in fasting blood glucose,total cholesterol,triacylglycerol,sex hormones(testosterone,estradiol and luteinizing hormone),myocardial enzymes[creatine kinase(CK),creatine kinase isozyme(CK-MB)and lactate dehydrogenase(LDH)]and the International Index of Erectile Function(IIEF-5)scores before treatment and after 2 months of treatment,and adverse drug reactions of two groups were compared.Results After 2 months of treatment,the levels of testosterone,estradiol and luteinizing hormone in the two groups were significantly higher than those before treatment.The levels of testosterone,estradiol and luteinizing hormone in the aripiprazole group were(4.89±0.47)ng/mL,(36.27±3.74)ng/mL and(6.21±0.68)mU/mL,respectively,which were significantly higher than those in the risperidone group[(4.05±0.41)ng/mL,(32.22±3.36)ng/mL,(5.11±0.52)mU/mL],the differences were statistically significant(P<0.05).After 2 months of treatment,the levels of CK,CK-MB and LDH in the two groups were significantly lower than those before treatment,and the levels of CK,CK-MB and LDH in the aripiprazole group were(111.34±11.23),(19.24±1.95)and(147.66±15.24)U/L,respectively,which were significantly higher than those

关 键 词：精神分裂症 男性 阿立哌唑 性激素 心肌酶谱 勃起功能 

分 类 号：R749.3[医药卫生—神经病学与精神病学]