不同子宫动脉介入栓塞方案治疗子宫肌瘤的临床疗效及对子宫血供、卵巢功能的影响  

Effect of different uterine artery interventional embolization on uterine fibroids and its influence on uterine blood supply and ovarian function

作　　者：高英 李莉 杨玉侠[1] GAO Ying;LI Li;YANG Yu-xia(Department of Obstetrics and Gynecology,Tangshan Maternal and Child Health Hospital,Tangshan Hebei 063000,China)

机构地区：[1]唐山市妇幼保健院妇产科,河北唐山063000

出　　处：《临床和实验医学杂志》2024年第15期1645-1649,共5页Journal of Clinical and Experimental Medicine

基　　金：河北省卫健委科研计划项目(编号:20240715)。

摘　　要：目的探讨子宫肌瘤治疗中不同子宫动脉介入栓塞方案的临床疗效及对子宫血供、卵巢功能的影响。方法回顾性选取2018年2月至2023年2月唐山市妇幼保健院收治的子宫肌瘤患者100例,依据子宫动脉介入栓塞方案不同分为三丙烯微球栓塞组和平阳霉素碘化油乳剂组,每组各50例。比较两组患者术前、术后6个月的子宫血供(子宫肌瘤内部、周边的最粗动脉血管径、收缩期峰值流速、平均流速、阻力指数)、卵巢功能[卵泡刺激素(FSH)、雌二醇、黄体生成素(LH)、孕酮]、子宫体积、肌瘤体积、平均月经期、平均月经量,并比较两组患者的临床疗效、术后综合征发生情况及复发情况。结果术后6个月,两组患者子宫肌瘤内部、周边的最粗动脉血管径、收缩期峰值流速、平均流速均低于术前,阻力指数均高于术前,差异均有统计学意义(P<0.05);两组患者术后6个月子宫肌瘤内部、周边的最粗动脉血管径、收缩期峰值流速、平均流速、阻力指数组间比较,差异均无统计学意义(P>0.05)。两组患者术后6个月的FSH、雌二醇、LH、孕酮水平与术前比较,差异均无统计学意义(P>0.05);且两组患者术后6个月的FSH、雌二醇、LH、孕酮水平组间比较,差异均无统计学意义(P>0.05)。术后6个月,两组患者的平均月经期均短于术前,平均月经量均少于术前,差异均有统计学意义(P<0.05);两组患者术后6个月的平均月经期、平均月经量组间比较,差异均无统计学意义(P>0.05)。三丙烯微球栓塞组患者的治疗总有效率(92.00%)与平阳霉素碘化油乳剂组患者(90.00%)相比,差异无统计学意义(P>0.05)。三丙烯微球栓塞组患者的术后综合征发生率为34.00%,明显低于平阳霉素碘化油乳剂组(64.00%),差异有统计学意义(P<0.05)。三丙烯微球栓塞组患者的复发率为0,明显低于平阳霉素碘化油乳剂组(12.00%),差异有统计学意义(P<0.05)。结论子�Objective To investigate the efficacy of different uterine artery embolization schemes in the treatment of uterine fibroids and the influence on uterine blood supply and ovarian function.Methods A total of 100 patients with uterine fibroids admitted to Tangshan Maternal and Child Health Hospital from February 2018 to February 2023 were retrospectively selected and divided into the tripropene microspheres group and the pingyangmycin iodized oil emulsion group according to the uterine artery interventional embolization scheme,with 50 cases each.Uterine blood supply(diameter of the thickest arteries inside and around uterine fibroids,peak systolic velocity,average velocity,resistance index),ovarian function[follicle stimulating hormone(FSH),estradiol,luteinizing hormone(LH),progesterone],uterine volume,fibroid volume,average menstrual period,average menstrual volume before operation and at 6 months after operation of the two groups were analyzed,the clinical efficacy,postoperative syndrome occurrence and recurrence of the two groups were analyzed.Results At 6 months after operation,the diameter of the thickest arterial blood inside and around the uterine fibroids,the peak systolic velocity and the average velocity of the two groups were lower than those before operation,and the resistance index was higher than that before operation,the differences were statistically significant(P<0.05).There were no statistically significant differences in the diameter of the thickest arterial blood,peak systolic velocity,average velocity and resistance index between the two groups at 6 months after operation(P>0.05).There were no statistically significant differences in the levels of FSH,estradiol,LH and progesterone between the two groups at 6 months after operation and before operation(P>0.05),and there was no statistically significant difference in the levels of FSH,estradiol,LH and progesterone between the two groups at 6 months after operation(P>0.05).At 6 months after operation,the average menstrual period of the two groups w

关 键 词：子宫肌瘤 卵巢 复发 子宫动脉介入栓塞 三丙烯微球 平阳霉素碘化油乳剂 子宫血供 卵巢功能 术后综合征 

分 类 号：R737.33[医药卫生—肿瘤]