非酒精性脂肪性肝病与溃疡性结肠炎的相关性分析  

Correlation analysis of nonalcoholic fatty liver disease and ulcerative colitis

作　　者：杨伟林 王奇[2] 吴玲云 张烁 Yang Weilin

机构地区：[1]浙江省中医院安吉分院,313300 [2]浙江中医药大学附属杭州市中医院,310007 [3]浙江中医药大学附属第二医院,310005

出　　处：《浙江临床医学》2024年第8期1126-1128,共3页Zhejiang Clinical Medical Journal

摘　　要：目的通过双向孟德尔随机化(MR)分析非酒精性脂肪性肝病(NAFLD)与溃疡性结肠炎(UC)相关性,明确两者的因果效应。方法选择全基因组关联研究统计数据库进行两样本双向MR分析。采用逆方差加权分析(IVW)、加权中位数、加权众数、MR-Egger回归以及MR多效性残差和离群值(MR-PRESSON)等方法。结果NAFLD对UC具备因果效应(OR=1.06,95%CI:1.01~1.11,P=0.01);逆向的因果关系分析未发现UC对NAFLD的因果效应。敏感性分析结果提示水平性多效性对因果估计值不会产生影响。结论NAFLD与UC间存在因果关系,包括逆向因果关系分析结果。Objective To analyze the correlation between Non-Alcoholic Fatty Liver Disease(NAFLD)and Ulcerative Colitis(UC)by two-way Mendelian Randomization analysis(MR),to clarify the causal effect of the two.Methods A genome-wide association study(GWAS)statistical database was selected for the two-way MR analysis of the tw o samples.Results Inverse-Variance Weighted(IVW),weighted median,weighted multinomial,MR-Egger regression and MR-PRESSON were used.Results NAFLD possessed a causal effect on UC(OR=1.06,95%CI:1.01~1.11,P=0.01),reverse causality analyses did not find a significant causal effect of UC on NAFLD.The results of sensitivity analyses suggested that horizontal pleiotropy would have no effect on the causal estimates.Conclusion A causal relationship exists between NAFLD and UC,including the results of the reverse causality analysis.

关 键 词：非酒精性脂肪性肝病 溃疡性结肠炎 孟德尔随机化分析 因果关系 

分 类 号：R575.5[医药卫生—消化系统] R574.62[医药卫生—内科学]