女贞牡蛎汤加减联合盐酸托莫西汀治疗儿童注意缺陷多动障碍的临床研究  

Clinical study on the treatment of attention deficit hyperactivity disorder in children with modified Ligustrum lucidum and oyster decoction combined with tomoxetine hydrochloride

作　　者：刘畅 宫延基 Liu Chang;Gong Yanji(Department of Child Healthcare,Jinhua Maternal&Child Health Care Hospital,Jinhua 321000,Zhejiang Province,China)

机构地区：[1]金华市妇幼保健院儿童保健科,金华321000

出　　处：《中国基层医药》2024年第8期1139-1143,共5页Chinese Journal of Primary Medicine and Pharmacy

基　　金：浙江省金华市科学技术研究计划(2021-4-306)。

摘　　要：目的:观察女贞牡蛎汤加减联合盐酸托莫西汀治疗儿童注意缺陷多动障碍的疗效。方法:选取2020年2月至2022年6月于金华市妇幼保健院治疗的注意缺陷多动障碍152例患儿作为研究对象,采用前瞻性的研究方法,按照倾向性评分匹配法分组,将研究对象分为对照组和观察组,各76例。对照组给予盐酸托莫西汀治疗,观察组在对照组的基础上,采用女贞牡蛎汤加减治疗;根据斯诺佩评估量表第四版(SNAP-Ⅳ)对患儿进行临床治疗效果评估;治疗后6个月,观察比较两组临床效果及治疗前、治疗后1~6个月相关指标变化。结果:治疗后2个月,两组SNAP-Ⅳ量表评分分别为(24.21±4.19)分和(20.75±4.74)分,均低于治疗后1个月的(32.45±3.23)分和(31.56±4.90)分(t=13.57、13.82,均P<0.05);治疗后3个月,两组SNAP-Ⅳ量表评分[(20.56±3.03)分和(17.28±3.06)分]均低于治疗后1个月、2个月(t=23.40、21.54、6.15、5.36,均P<0.05);治疗后6个月,两组SNAP-Ⅳ量表评分[(18.34±4.28)分和(13.87±2.89)分]均低于低于治疗后1、2、3个月(t=22.94、27.10、8.54、10.80、3.69、7.06,均P<0.05),且观察组治疗后2、3、6个月SNAP-Ⅳ量表评分均低于对照组(t=4.76、6.64、7.54,均P<0.001);观察组的总有效率为81.58%(62/76),明显高于对照组的60.53%(46/76)(χ^(2)=8.18,P<0.05);观察组不良反应发生率为5.26%(4/76),与对照组的9.21%(7/76)比较,差异无统计学意义(P>0.05)。结论:女贞牡蛎汤加减联合盐酸托莫西汀治疗儿童注意缺陷多动障碍效果优于单一盐酸托莫西汀治疗,且无明显的不良反应。Objective To investigate the clinical efficacy of modified Ligustrum lucidum and oyster decoction combined with tomoxetine hydrochloride in the treatment of attention deficit hyperactivity disorder in children.Methods A total of 152 children with attention deficit hyperactivity disorder who were treated at Jinhua Maternal&Child Health Care Hospital from February 2020 to June 2022 were included in this study.Using a prospective study approach,the patients were divided into two groups based on the propensity score matching method:76 patients in the control group and 76 patients in the observation group.The control group was treated with tomoxetine hydrochloride,while the observation group received modified Ligustrum lucidum and oyster decoction combined with tomoxetine hydrochloride.Clinical treatment effects on the children were evaluated using the Swanson,Nolan,and Pelham Rating Scale-versionⅣ(SNAP-Ⅳ).Six months after treatment,the clinical efficacy of both groups was observed and compared.In addition,changes in relevant indicators from before treatment to 6 months post-treatment were compared.Results At 2 months of treatment,the SNAP-Ⅳscores for the control and observation groups were(24.21±4.19)points and(20.75±4.74)points,respectively,which were significantly lower than those measured at 1 month of treatment[(32.45±3.23)points,(31.56±4.90)points,t=13.57,13.82,both P<0.05].At 3 months of treatment,the SNAP-Ⅳscores for the control and observation groups were(20.56±3.03)points and(17.28±3.06)points,respectively,which were significantly lower than those measured at 1 and 2 months of treatment(t=23.40,21.54,6.15,5.36,all P<0.05).At 6 months of treatment,the SNAP-Ⅳscores for the control and observation groups were(18.34±4.28)points and(13.87±2.89)points,respectively,which were significantly lower than those measured at 1,2 and 3 months of treatment(t=22.94,27.10,8.54,10.80,3.69,7.06,all P<0.05).At 2,3,and 6 months of treatment,the SNAP-Ⅳscores for the observation group were significantly lower th

关 键 词：注意力缺陷障碍伴多动 女贞属 牡蛎属 中草药 盐酸托莫西汀 儿童 

分 类 号：R749.94[医药卫生—神经病学与精神病学]