臭氧局部注射联合舒马曲坦治疗顽固性偏头痛的效果  

Effects of Ozone Local Injection Combined with Sumatriptan in the Treatment of Intractable Migraine

作　　者：曹现芳[1] CAO Xianfang(Department of Neurology,the Second Affiliated Hospital of Henan University of Science and Technology,Luoyang 471000,China)

机构地区：[1]河南科技大学第二附属医院神经内科,河南洛阳471000

出　　处：《河南医学研究》2024年第18期3399-3401,共3页Henan Medical Research

摘　　要：目的观察臭氧局部注射联合舒马曲坦治疗顽固性偏头痛的效果。方法入选2021年2月至2023年2月河南科技大学第二附属医院85例顽固性偏头痛患者,按随机数表法分为研究组(43例)和对照组(42例)。对照组接受舒马曲坦治疗,研究组在对照组基础上加用臭氧局部注射治疗。比较两组血清学指标[5-羟色胺(5-HT)、白介素-6(IL-6)、肿瘤坏死因子α(TNF-α)]、头痛发作频次、发作持续时间、发作程度[视觉模拟评分法(VAS)];统计不良反应。结果治疗后,两组5-HT、IL-6、TNF-α降低,且研究组更低(P<0.05)。治疗后,两组头痛发作频次减少,且研究组更少(P<0.05);两组头痛发作持续时间缩短,且研究组更短(P<0.05);两组VAS评分降低,且研究组更低(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论臭氧局部注射联合舒马曲坦治疗顽固性偏头痛能提高镇痛效果,且安全性较好。Objective To observe the efficacy of ozone local injection combined with sumatriptan in the treatment of intractable migraine.Methods A total of 85 patients with intractable migraine admitted to the Second Affiliated Hospital of Henan University of Science and Technology from February 2021 to February 2023 were randomly divided into the study group(43 cases)and the control group(42 cases).The control group was treated with sumatriptan,while the study group received ozone local injection in addition to the control group.The serological indexes[5-hydroxytryptamine(5-HT),interleukin-6(IL-6),tumor necrosis factorα(TNF-α)],headache attack frequency,attack duration and attack degree[visual analogue scale(VAS)]were compared between the two groups.Adverse reactions were counted.Results After treatment,the levels of 5-HT,IL-6 and TNF-αin the two groups decreased,and those in the study group were lower(P<0.05).After treatment,the frequency of headache attacks in the two groups decreased,and the study group was less(P<0.05).After treatment,the duration of headache attacks in the two groups was shortened,and the study group was shorter(P<0.05).After treatment,the VAS scores of the two groups decreased,and the study group was lower(P<0.05).There was no difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Ozone local injection combined with sumatriptan can improve the analgesic effect and has good safety in the treatment of refractory migraine.

关 键 词：顽固性偏头痛 臭氧局部注射 舒马曲坦 

分 类 号：R747.2[医药卫生—神经病学与精神病学]