类器官技术在胰腺癌放射治疗中的研究与应用前景  

Research and Application Prospect of Organoid Technique in Radiotherapy of Pancreatic Cancer

作　　者：童姣姣 梁译尹 陈亮 许碧纯 张火俊 TONG Jiaojiao;LIANG Yiyin;CHEN Liang;XU Bichun;ZHANG Huojun(Department of Radiation Oncology,The First Affiliated Hospital of Naval Medical University,Shanghai 200433,China)

机构地区：[1]海军军医大学第一附属医院放射治疗科,上海200433

出　　处：《肿瘤防治研究》2024年第9期784-788,共5页Cancer Research on Prevention and Treatment

基　　金：国家自然科学基金面上项目(82272742);上海卫生健康委员会领军人才计划(2022LJ019);科技部国家重点研发计划(2022YFC2503701);长海医院“固海”计划(GH145-33)。

摘　　要：胰腺癌作为一种常见的消化系统恶性肿瘤,生存率极低。近年来,胰腺癌在诊断方法、放射治疗技术和全身化疗等方面取得了较大进展,但其治疗效果并没有明显提高。类器官作为一种新型肿瘤研究平台,已在多个领域取得研究进展,通过构建胰腺癌类器官对胰腺癌的个体化治疗进行指导具有重要研究价值。本文对类器官模型在胰腺癌放射治疗中的研究及临床应用前景进行综述。Pancreatic cancer,as a common malignant tumor of the digestive system,has a very low survival rate.In recent years,pancreatic cancer has made great progress in diagnostic methods,radiation therapy techniques,and systemic chemotherapy,but its therapeutic effect has not been considerably improved.As a new type of tumor research platform,organoids have made research progress in many fields.Constructing pancreatic cancer organoids is of great research value to guide the individualized treatment of pancreatic cancer.This article reviews the research and clinical application prospect of organoid model in radiotherapy of pancreatic cancer.

关 键 词：胰腺癌 类器官 肿瘤模型 放射治疗 

分 类 号：R735.9[医药卫生—肿瘤]