瘤胃球菌与结直肠癌的关系及其影响胃肠道的机制探讨  

Relationship Between Ruminococcus and Colorectal Cancer and Its Anti-Cancer Mechanism

作　　者：蔡志阳 金黑鹰 张春霞 舒磊 刘曜安 CAI Zhiyang;JIN Heiying;ZHANG Chunxia;SHU Lei;LIU Yaoan(Department of Anorectal Surgery,Jiangsu Provincial Second Chinese Medicine Hospital(The Second Affiliated Hospital of Nanjing University of Chinese Medicine),Nanjing 210017,China)

机构地区：[1]南京中医药大学第二附属医院(江苏省第二中医院)肛肠外科,南京210017

出　　处：《肿瘤防治研究》2024年第9期789-793,共5页Cancer Research on Prevention and Treatment

基　　金：江苏省科技项目基金资助(BE2023786);江苏省中医药科技发展计划项目基金资助(MS2023047)。

摘　　要：近年研究发现,肠道菌群参与了结直肠癌的发生和发展全过程,其中瘤胃球菌属在结直肠癌患者中丰度降低,且瘤胃球菌属可以通过交叉喂养、促丁酸盐生成等途径来影响胃肠道健康。虽然现阶段对于瘤胃球菌的研究正在逐步增加,但就瘤胃球菌属对于结直肠癌发生发展的影响,仍未有统一的认识,基于此,现就瘤胃球菌属与结直肠癌的关系和可能存在的抑癌机制作一概述,为未来深入探究结直肠癌生物预防及治疗提供理论依据。Recent studies found that the intestinal flora is involved in the occurrence and development of CRC.In particular,Ruminococcus shows a decreased abundance in patients with CRC and can affect gastrointestinal health through cross-feeding and promoting butyrate production.Although the research on Ruminococcus is gradually increasing,no unified understanding of its influence on the occurrence and development of CRC has been established.This work summarizes the relationship of Ruminococcus with CRC and its possible anticancer mechanism to provide a theoretical basis for the further exploration of biological prevention and treatment of CRC in the future.

关 键 词：结直肠癌 肠道菌群 瘤胃球菌属 布氏瘤胃球菌 伶俐瘤胃球菌 丁酸盐 

分 类 号：R735.5[医药卫生—肿瘤]