抗菌肽在口腔钛种植体涂层中的研究进展  

Advancements in the study of antimicrobial peptides in the coating of oral titanium implants

作　　者：李佳敏 李毓晨 葛张洁 廖凌子 郭鑫 郭晓龙 周平[1,2,4] Li Jiamin;Li Yuchen;Ge Zhangjie;Liao Lingzi;Guo Xin;Guo Xiaolong;Zhou Ping(School of Stomatology,Lanzhou University,Lanzhou 730000,China;Key Laboratory of Dental Maxillofacial Reconstruction and Biological Intelligence Manufacturing in Gansu Province,Lanzhou 730000,China;Dept.of Stomatology,Gansu Provincial Hospital,Lanzhou 730000,China;Dept.of Oral and Maxillofacial Surgery,Hospital of Stomatology,Lanzhou University,Lanzhou 730000,China)

机构地区：[1]兰州大学口腔医学院,兰州730000 [2]甘肃省牙颌面重建与生物智能制造重点实验室,兰州730000 [3]甘肃省人民医院口腔科,兰州730000 [4]兰州大学口腔医院颌面外科,兰州730000

出　　处：《国际口腔医学杂志》2024年第5期572-584,共13页International Journal of Stomatology

基　　金：中国博士后科学基金(2022M721443);兰州大学学生创新创业行动计划(20220150019)。

摘　　要：口腔钛种植体的临床需求与日俱增,为预防种植体周疾病、提高种植成功率,种植体的表面修饰是目前研究的一大热点。影响种植体远期治疗效果的主要因素是种植体周炎所导致的骨丧失,理想的种植体应在具有良好的抗菌性能的同时,具备优异的骨整合性能。与传统涂层相比,抗菌肽(AMP)具有优良的抗菌性能等多方面优势。本文介绍了种植体周疾病的发病机制和AMP的分类及作用机制,并从增强抗菌性能、促进骨结合、响应种植体周围组织变化这三方面对现有种植体表面AMP涂层作一综述,以期为AMP涂层研究的优化及其临床转化指明方向。The demand for oral titanium implants is growing.Thus,strategies preventing peri-implant disease and improving the success rate of implantation through the surface modification of implants have been extensively studied.The main factor affecting the long-term therapeutic outcome of implants is bone loss due to peri-implantitis.Hence,an ideal implant should have not only good antimicrobial properties but also excellent osseointegration properties.Compared with conventional coatings,antimicrobial peptides(AMPs)have excellent antimicrobial properties.This paper introduces the pathogenesis of peri-implant diseases and the classification and mechanism of action of AMPs.In addition,existing AMP coatings on implant surfaces are examined in terms of their efficiency in enhancing AMPs,promoting osseointegration,and responding to changes in peri-implant tissues.This study is expected to provide a direction for the optimization of AMP coating research and its clinical translation.

关 键 词：抗菌肽 钛种植体 种植体周炎 表面改性 抗菌 骨整合 

分 类 号：R783.1[医药卫生—口腔医学]