脂溶性维生素的生物合成  

Biosynthesis of fat-soluble vitamins

作　　者：张博[1,2] 余浩楠 朱丽丹 朱溢 柳志强 郑裕国[1,2] ZHANG Bo;YU Haonan;ZHU Lidan;ZHU Yi;LIU Zhiqiang;ZHENG Yuguo(The National and Local Joint Engineering Research Center for Biomanufacturing of Chiral Chemicals,Zhejiang University of Technology,Hangzhou 310014,Zhejiang,China;Key Laboratory of Bioorganic Synthesis of Zhejiang Province,College of Biotechnology and Bioengineering,Zhejiang University of Technology,Hangzhou 310014,Zhejiang,China)

机构地区：[1]浙江工业大学手性生物制造国家地方联合工程研究中心,浙江杭州310014 [2]浙江工业大学生物工程学院浙江省生物有机合成技术研究重点实验室,浙江杭州310014

出　　处：《生物工程学报》2024年第8期2552-2569,共18页Chinese Journal of Biotechnology

基　　金：国家重点研发计划(2018YFA0901400);国家自然科学基金(32070099,31971342)。

摘　　要：维生素是人体正常生命活动所必需的一种有机物质,近年来维生素的应用场景不断扩展,除食品、畜牧业领域外,在医药、美妆等行业也有广泛应用,因此全球市场对维生素的需求不断增长。随着近几年合成生物学的快速发展,在现有的维生素生产方法中生物合成法因具有环保、安全、效率高等优点,逐渐被行业研究者所关注。为了进一步实现低碳、节能、减排以及我国“碳达峰”和“碳中和”的目标,建立和实现生物合成维生素的方法具有较大的应用价值。本文综述了近年来生物合成在维生素生产领域的研究进展,详细阐述了脂溶性维生素(维生素A、维生素D、维生素E和维生素K)的生物合成研究现状。Vitamins are the essential organic substances to ensure the normal life activities of the human body.At present,vitamins are widely used in the pharmaceutical,food,animal farming,beauty and other industries,appearing in increasing application scenarios.Accordingly,the global demand for vitamins has also increased greatly.The current methods of vitamin production mainly include chemical synthesis and biosynthesis,with the latter being greener,more environmentally friendly,safer,and lower in energy consumption.Establishing the method for the biosynthesis of vitamins is of great scientific significance for achieving the goals of low carbon,energy saving,and emission reduction,as well as carbon emission peak and carbon neutrality in China.This paper reviews the research progress in the biosynthesis of vitamins,especially fat-soluble vitamins(vitamins A,D,E,and K),in recent years.

关 键 词：脂溶性维生素 生物合成 生物发酵 代谢工程 合成生物学 新质生产力 

分 类 号：TQ466[化学工程—制药化工]