微生物利用CO_(2)及其低碳衍生物为原料制备粮食类产物的研究进展  

Microbial production of food compounds with carbon dioxide and derived low-carbon molecules as substrates

作　　者：白振敏 郭姝媛 杨一群 庄周康 曹文兵 杨研 于涛 汤红婷 BAI Zhenmin;GUO Shuyuan;YANG Yiqun;ZHUANG Zhoukang;CAO Wenbing;YANG Yan;YU Tao;TANG Hongting(China BlueChemical Ltd.,Beijing 100029,China;Center for Synthetic Biochemistry,Shenzhen Institute of Synthetic Biology,Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055,Guangdong,China;CAS Key Laboratory of Quantitative Engineering Biology,Shenzhen Institute of Synthetic Biology,Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055,Guangdong,China;Carbon Neutrality and Food Security Cross-Innovation Joint Laboratory,Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055,Guangdong,China)

机构地区：[1]中海石油化学股份有限公司,北京100029 [2]中国科学院深圳先进技术研究院、深圳合成生物学创新研究院合成生物化学研究中心,广东深圳518055 [3]中国科学院深圳先进技术研究院、深圳合成生物学创新研究院定量合成生物学重点实验室,深圳518055 [4]中国科学院深圳先进技术研究院碳中和与粮食安全交叉创新联合实验室,广东深圳518055

出　　处：《生物工程学报》2024年第8期2731-2746,共16页Chinese Journal of Biotechnology

基　　金：国家重点研发计划(2021YFA0911000);国家自然科学基金(32071416);广东省重点区域研究与发展计划项目(2022B1111080005);深圳合成生物学创新研究院科研基金(JCHZ20200003);深圳市科技计划(ZDSYS20210623091810032);中国科学院战略重点研究项目(XDB0480000)。

摘　　要：微生物细胞工厂的构建和优化是实现绿色生物制造的重要环节和关键技术。现阶段,过量二氧化碳(CO_(2))排放和粮食短缺等问题已经引起了广泛关注,这促进了利用人工微生物将CO_(2)转化为粮食类化合物这一新兴研究方向的发展。该领域的研究不仅有助于实现“双碳”目标,也对维护粮食安全具有重大意义。本文主要围绕葡萄糖、糖类衍生物、单细胞蛋白的生物合成及人工碳固定途径的开发及应用等方面,对直接或者间接利用CO_(2)制备粮食类化合物的研究进展进行了综述和展望。The construction and optimization of microbial cell factories are crucial steps and key technologies in achieving green biomanufacturing.As concern has been aroused regarding the excessive carbon dioxide(CO_(2))emissions and food security,a new and promising research field,microbial conversion of CO_(2) into food compounds,has emerged.The research in this field not only holds significant implications for achieving the carbon peaking and carbon neutrality goals but also plays a role in maintaining food security.This paper provides a comprehensive review and outlook of the research on utilizing CO_(2) and its derived low-carbon chemicals for the production of food compounds,focusing on the production of glucose,sugar derivatives,and single-cell proteins and the development of artificial CO_(2) fixation pathways.

关 键 词：二氧化碳 低碳原料 粮食类化合物 糖类衍生物 单细胞蛋白 

分 类 号：X701[环境科学与工程—环境工程] TS210.1[轻工技术与工程—粮食、油脂及植物蛋白工程]