TyG指数联合CA153和CEA在诊断乳腺恶性肿瘤中的价值  

The value of TyG index combined with CA153 and CEA in the diagnosis of breast malignant tumors

作　　者：程娟[1] 姚杰[1] 唐伟 韦玉[1] 周强[1] CHENG Juan;YAO Jie;TANG Wei;WEI Yu;ZHOU Qiang(Department of Clinical Laboratory,the Second Affiliated Hospital of Anhui Medical University,Hefei,Anhui 230601,China)

机构地区：[1]安徽医科大学第二附属医院检验科,安徽合肥230601

出　　处：《热带医学杂志》2024年第8期1192-1195,F0003,共5页Journal of Tropical Medicine

基　　金：国家自然科学基金青年基金(82102460)。

摘　　要：目的研究甘油三酯-葡萄糖(TyG)指数联合癌抗原153(CA153)和癌胚抗原(CEA)在乳腺良恶性肿瘤鉴别诊断中的价值。方法选取2021年1月-2024年4月期间就诊于安徽医科大学第二附属医院的42例乳腺恶性肿瘤患者为观察组,40例乳腺良性疾病为对照组,检测所有研究对象术前外周血TyG指数及CA153和CEA,对比两组TyG指数及CA153、CEA水平的差异,分析TyG指数和CA153、CEA的相关性,并评估TyG指数、CA153、CEA单独及联合在诊断乳腺恶性肿瘤方面的敏感度和特异度。结果观察组患者术前TyG指数、CA153、CEA水平较对照组均显著升高,差异均有统计学意义(t=4.56、4.87、4.90,P均<0.01);TyG指数与CA153、CEA成正相关(r=0.700、0.574,P均<0.01)。TyG指数的曲线下面积(AUC)为0.825,敏感度为71.4%,特异度为83.3%;TyG指数联合CA153、CEA的AUC为0.865,敏感度为85.7%,特异度为77.8%,TyG指数联合CA153、CEA敏感度最高,特异度CA153最高。结论TyG指数联合CA153、CEA在乳腺恶性肿瘤诊断中有辅助价值。Objective To study the value of triglyceride⁃glucose(TyG)index combined with cancer antigen 153(CA153)and carcinoembryonic antigen(CEA)in the differential diagnosis of benign and malignant breast tumors.Methods A total of 42 patients with breast malignant tumors who visited the Second Affiliated Hospital of Anhui Medical University from January 2021 to April 2024 were selected as the observation group,and 40 patients with benign breast diseases were selected as the control group.Preoperative peripheral blood TyG index,CA153,and CEA levels were measured in all study subjects.The differences in TyG index,CA153,and CEA levels between the two groups were compared.The correlation between TyG index,CA153,and CEA was analyzed,and the sensitivity and specificity of TyG index,CA153,CEA alone and in combination in diagnosing breast malignant tumors were evaluated.Results The preoperative TyG index,CA153,and CEA levels in the observation group were significantly higher than those in the control group(t=4.56,4.87,4.90;all P<0.01).The TyG index was closely related to CA153 and CEA(r=0.700,0.574;all P<0.01).The area under the curve(AUC)of the TyG index was 0.825,with a sensitivity of 71.4%and a specificity of 83.3%.The AUC of TyG index combined with CA153 and CEA was 0.865,with a sensitivity of 85.7%and specificity of 77.8%.The TyG index combined with CA153 and CEA had the highest sensitivity,and CA153 had the highest specificity.Conclusion The TyG index combined with CA153 and CEA had auxiliary value in the diagnosis of breast malignant tumors.

关 键 词：TyG指数 癌抗原153 癌胚抗原 乳腺恶性肿瘤 

分 类 号：R737.9[医药卫生—肿瘤]