2018-2022年郑州市81606例女性HPV基因分型感染趋势分析  

Trend of HPV genotypes in 81606 female patients in Zhengzhou city from 2018 to 2022

作　　者：葛洁洁 吕朋举 关红亚 黄永杰 GE Jiejie;LÜPengju;GUAN Hongya;HUANG Yongjie(Department of Clinical Laboratory,Zhengzhou Central Hospital Affiliated to Zhengzhou University,Zhengzhou,Henan 450007,China;Translational Medical Center,Zhengzhou Central Hospital Affiliated to Zhengzhou University,Zhengzhou,Henan 450007,China)

机构地区：[1]郑州大学附属郑州中心医院检验科,河南郑州450007 [2]郑州大学附属郑州中心医院转化医学中心,河南郑州450007

出　　处：《热带医学杂志》2024年第8期1205-1209,共5页Journal of Tropical Medicine

基　　金：河南省医学科技攻关联合共建项目(LHGJ20220862)。

摘　　要：目的研究2018-2022年郑州地区女性人乳头瘤病毒(HPV)的感染趋势及亚型、年龄分布特点。方法选取2018年1月-2022年6月期间参加郑州大学附属郑州中心医院HPV感染筛查的24316例适龄妇女为体检组;选取同期医院妇科就诊HPV感染筛查的57290例适龄妇女为就诊组,共81606例。采用荧光PCR技术筛查21种HPV基因亚型,对数据进行统计分析。结果体检组有1921例宫颈标本HPV为阳性,总感染率和二价、四价、九价HPV疫苗型感染率分别为:7.90%、1.60%、1.85%、4.93%,而就诊组有6411例HPV阳性标本,总感染率和二价、四价、九价HPV疫苗型感染率分别为:11.19%、3.00%、3.95%、7.51%。HPV感染率前6位为:HPV-16/52/58/53/39/51型,体检组中HPV感染的高发年龄段为56~<61岁(11.64%),就诊组为15~<21岁(25.17%),2018-2022年HPV女性感染率分别是:18.67%、11.02%、7.90%、9.35%、9.05%,近5年总的HPV感染率为10.21%。结论HPV感染存在年龄差异;九价HPV疫苗的扩龄非常有必要;2018-2022年HPV的感染率呈现降低趋势。Objective To investigate the subtype and age distribution of human papilloma virus(HPV)infection in women in Zhengzhou from 2018 to 2022.Methods A total of 24316 women of appropriate age who participated in HPV infection screening in the Zhengzhou Central Hospital Affiliated to Zhengzhou University from January 2018 to June 2022 were selected as the examination group.57290 women of appropriate age who received HPV infection screening in the gynecological of the hospital during the same period were selected as the patient group.Fluorescent PCR was used to screen 21 HPV gene subtypes,and the data were analyzed statistically.Results In the examination group,1921 cases of cervical specimens were HPV positive,the total infection rate and the infection rates of bivalent,quadvalent and nine⁃valent HPV vaccine types were 7.90%,1.60%,1.85%,4.93%,respectively,while in the patient group,there were 6411 cases of HPV positive specimens,the infection rates were:11.19%,3.00%,3.95%,7.51%,respectively.The top six female HPV infection rates were:HPV⁃16/52/58/53/39/51.The age group with high incidence of HPV infection was 56-<61 years(11.64%)in the examination group,while 15-<21 years(25.17%)in the treatment group.The women HPV infection rate from 2018 to 2022 was 18.67%,11.02%,7.90%,9.35%and 9.05%,respectively,and the average HPV infection rate in the past five years was 10.21%.Conclusions HPV infection varies by age.The nine⁃valent HPV vaccination need to expend the age range urgently.The infection rate of HPV showed a decreasing trend from 2018 to 2022.

关 键 词：宫颈癌 人乳头瘤病毒 基因分型 感染率 疫苗 

分 类 号：R737.33[医药卫生—肿瘤]