S100A8/S100A9在视网膜退行性疾病中的作用及机制研究进展  

Research progress on the role and mechanism of S100A8/S100A9 in retinal degenerative diseases

作　　者：黄伟迪 陆才洋 陈树明 唐子淳 李勰 郑淑燕 黄茜璇 刘骁 李卓[1] Huang Weidi;Lu Caiyang;Chen Shuming;Tang Zichun;Li Xie;Zheng Shuyan;Huang Xixuan;Liu Xiao;Li Zhuo(Department of Ophthalmology,the Second Xiangya Hospital,Central South University,Changsha 410011,Hunan Province,China;Hunan Center for Drug Evaluation and ADR Monitoring,Changsha 410013,Hunan Province,China)

机构地区：[1]中南大学湘雅二医院眼科,湖南省长沙市410011 [2]湖南省药品审评与不良反应监测中心,湖南省长沙市410013

出　　处：《国际眼科杂志》2024年第10期1610-1614,共5页International Eye Science

基　　金：湖南省自然科学基金项目(No.2023JJ60137,2023JJ30770)。

摘　　要：S100蛋白家族属于损伤相关分子模式(DAMP),其在机体先天免疫反应中发挥着重要的炎症调节作用。其中S100A8/S100A9蛋白在众多疾病中发挥着广泛的抗菌、抗感染功能,并促进机体免疫及炎症反应的发生发展。在各类视网膜退行性疾病中,S100A8/S100A9蛋白在转录及翻译阶段均明显上调,可促进眼部组织炎症因子的激活、巨噬细胞和中性粒细胞等免疫细胞的激活与募集,促进眼部炎症发生发展。文章旨在阐述S100A8/S100A9蛋白的生物学功能及其在视网膜退行性疾病如糖尿病视网膜病变、年龄相关性黄斑变性和缺血性视网膜病变中的作用及可能的机制。The S100 protein family is a key component of damage-associated molecular patterns(DAMP),which play a vital role in regulating inflammation in the body’s innate immune response.S100A8/S100A9 proteins play a wide range of antibacterial and anti-infective functions in many diseases,and promote the occurrence and development of the body’s immune and inflammatory responses.In various retinal degenerative diseases,S100A8/S100A9 proteins are significantly upregulated at the transcription and translation stages,promoting the activation of inflammatory factors in ocular tissues,the activation and recruitment of immune cells such as macrophages and neutrophils,and the occurrence and development of ocular inflammation.This review aimsat explaining the biological functions of S100A8/S100A9 proteins and their roles and possible mechanisms in retinal degenerative diseases such as diabetic retinopathy,age-related macular degeneration and ischemic retinopathy.

关 键 词：损伤相关分子模式(DAMP) S100A8/S100A9蛋白 糖尿病视网膜病变 炎症 视网膜退行性疾病 

分 类 号：R774.1[医药卫生—眼科]