CD4^(+)CD8^(-)T细胞大颗粒淋巴细胞白血病的临床分析  

Clinical Analysis of CD4^(+)CD8^(-)T-Cell Large Granular Lymphocytic Leukemia

作　　者：常香香 孙尚彪 李玉文 王淼 朱燕青[1] CHANG Xiang-Xiang;SUN Shang-Biao;LI Yu-Wen;WANG Miao;ZHU Yan-Qing(Department of Hematology,Linquan People’s Hospital,Linquan 236400,Anhui Province,China)

机构地区：[1]临泉县人民医院血液内科,安徽临泉236400

出　　处：《中国实验血液学杂志》2024年第5期1388-1393,共6页Journal of Experimental Hematology

摘　　要：目的:探讨CD4^(+)CD8^(-)T细胞大颗粒淋巴细胞白血病(T-LGLL)患者的临床特征及诊疗方案。方法:报告1例CD4^(+)CD8^(-)T-LGLL患者的临床表现、诊断及治疗情况,并结合文献进行回顾性分析。结果:患者为老年女性(70岁),临床进展缓慢,以血小板减少为主要表现,骨髓增生较低下,血涂片以大颗粒淋巴细胞为主,免疫分型及T细胞克隆重排符合T-LGLL应用环磷酰胺50 mg/d联合泼尼松(后逐渐减停)治疗,达到部分缓解(PR)。结论:CD4^(+)CD8^(-)T细胞大颗粒淋巴细胞白血病临床上极为罕见,与CD4^(-)CD8^(+)T-LGLL临床表现存在差异。Objective:To investigate the clinical characteristics and treatment of patients with CD4^(+)CD8^(-)T-cell large granular lymphocytic leukemia(T-LGLL).Methods:The clinical manifestations,diagnosis and treatment of 1 case of CD4^(+)CD8^(-)T-LGLL patient were reported,and relevant literatures were reviewed.Results:The patient was a 70-year-old woman with slow clinical progress,mainly manifested by thrombocytopenia and myelodysplasia.The blood smear was mainly composed of large granular lymphocytes.Immunotyping and T-cell receptor gene rearrangement analysis showed that it was in line with T-LGLL.Partial remission(PR)was achieved through the treatment of cyclophosphamide(50 mg/d)combined with prednisone(gradually reduced and stopped later).Conclusion:CD4^(+)CD8^(-)T-LGLL is very rare in clinical practice,and its clinical manifestations are different from those of CD4^(+)CD8^(-)T-LGLL.

关 键 词：CD4^(+)CD8^(-)T细胞大颗粒淋巴细胞白血病 临床表现 治疗 

分 类 号：R733.7[医药卫生—肿瘤]