内皮激活和应激指数(EASIX)对外周T细胞淋巴瘤患者预后的影响  

Effect of Endothelial Activation and Stress Index(EASIX)on Prognosis of Peripheral T-Cell Lymphoma Patients

作　　者：陈惠敏 马瑞雪 张芊芊 陆丰艺 胡瑾 韩倩楠 李振宇 徐开林 陈伟 CHEN Hui-Min;MA Rui-Xue;ZHANG Qian-Qian;LU Feng-Yi;HU Jin;HAN Qian-Nan;LI Zhen-Yu;XU Kai-Lin;CHEN Wei(Department of Hematology,The Afiliated Hospital of Xuzhou Medical University,Xuzhou 221002,Jiangsu Province,China;Department of Hematology,The First Peoples Hospital of Suqian,Suqian 223800,Jiangsu Province,China)

机构地区：[1]徐州医科大学附属医院血液科,江苏徐州221002 [2]江苏省宿迁市第一人民医院血液科,江苏宿迁223800

出　　处：《中国实验血液学杂志》2024年第5期1394-1400,共7页Journal of Experimental Hematology

基　　金：江苏省自然科学基金(BK20161177、BK20221218);徐州医科大学附属医院发展基金(XYFY2021001);宿迁市血液学重点实验室(M202111)。

摘　　要：目的:探讨内皮激活和应激指数(EASIX)对血管免疫母细胞性T细胞淋巴瘤(AITL)和外周T细胞淋巴瘤非特指型(PTCL-NOS)患者预后的影响,并比较低EASIX组和高EASIX组患者的临床特征。方法:回顾性分析2010年1月至2021年9月由徐州医科大学附属医院收治的59例初诊AITL和PTCL-NOS患者的临床资料通过受试者工作特征(ROC)曲线确定EASIX的最佳截断值,卡方检验分析EASIX与AITL和PTCL-NOS患者临床特征的相关性,Kaplan-Meier生存曲线分析患者的总生存期(OS)和无进展生存期(PFS),Cox比例风险模型进行单因素与多因素分析。结果:EASIX的最佳截断值为0.95以此为界将患者分为低EASIX(<0.95)组和高EASIX(≥0.95)组。与低EASIX组患者相比,高EASIX组PTCL患者具有Ann Arbor分期晚、IPI评分高中危以上、LDH升高、易发生低白蛋白血症与贫血、易合并B症状、结外累及和骨髓累及等临床特点。生存分析结果显示,59例PTCL患者中,高EASIX组患者的OS和PFS较低EASIX组患者均明显缩短(P<0.001)。多因素分析结果显示,EASIX是影响患者OS[HR=7.217(95%CI:1.959-26.587),(P=0.003)]和PFS[HR=2.718(95%CI:1.032-7.161),P=0.043]的独立危险因素。结论:初诊AITL和PTCL-NOS患者高EASIX提示患者预后不良,高EASIX是影响患者预后的危险因素。Objective:To investigate the effect of endothelial activation and stress index(EASIX)on the prognosis of patients with angioimmunoblastic T-cell lymphoma(AITL)and peripheral T-cell lymphoma,not otherwise specified(PTCLNOS),and to compare the clinical characteristics of patients in the low EASIX and high EASIX groups.Methods:The clinical data of 59 newly diagnosed AITL and PTCL-NOS patients admitted to the Affiliated Hospital of Xuzhou Medical University from January 2010 to September 2021 were retrospectively analyzed.The optimal cut-off value of EASIX was determined by receiver operating characteristic(ROC)curve;The chi-square test was used to analyze the correlation between EASIX and clinical features of patients with AITL and PTCL-NOS;The Kaplan-Meier survival curve was used to analyze the overall survival(OS)and progression-free survival(PFS)of the patients;Univariate and multivariate analyses were performed by using Cox proportional hazards model.Results:The optimal cut-off value of EASIX was 0.95,based on which the patients were divided into a low EASIX(<0.95)group and a high EASIX(≥0.95)group.Compared with the low EASIX group,the high EASIX group had a higher proportion of patients with advanced Ann Arbor stage,higher risk according to IPI,elevated LDH,hypoproteinemia,anemia,B symptoms,extranodal involvement,and bone marrow involvement.Survival analysis showed that the OS and PFS of patients in the high EASIX group were significantly shorter than those in the lower EASIX group(P<0.001).The.multivariate analysis showed that EASIX was an independent risk factor for OS[HR=7.217(95%CI:1.959-26.587),P=0.003]and PFS[HR=2.718(95%CI:1.032-7.161),P=0.043]of PTCL patients.Conclusion:.High EASIX in newly diagnosed patients with AITL and PTCL-NOS suggests a poor prognosis,and high EASIX is a risk factor affecting prognosis of the patients.

关 键 词：外周T细胞淋巴瘤 血管免疫母细胞性T细胞淋巴瘤 外周T细胞淋巴瘤非特指型 内皮激活和应激指数 

分 类 号：R733.1[医药卫生—肿瘤]