自噬途径在药物治疗多发性骨髓瘤中作用的研究进展  

Research Progress on the Role of Autophagy Pathway in the Pharmacological Treatment of Multiple Myeloma——Review

作　　者：王玮[1] 张青 张志华[1] WANG Wei;ZHANG Qing;ZHANG Zhi-Hua(Department of Hematology,The Affiliated Hospital of Chengde Medical College,Chengde 067000,Hebei Province,China)

机构地区：[1]承德医学院附属医院血液内科,河北承德067000

出　　处：《中国实验血液学杂志》2024年第5期1618-1621,共4页Journal of Experimental Hematology

基　　金：2022年河北省省级课题计划(自然科学基金)(H20222406041)。

摘　　要：多发性骨髓瘤(MM)是一种恶性血液肿瘤,其治疗常依赖于蛋白酶体抑制剂、免疫调节剂、类固醇等药物,但多数MM仍然会面临复发或转为难治性。自噬是一种2型细胞死亡机制,在MM病情进展中起着关键作用,包括促进MM细胞存活或促进其死亡的双相调控作用。本文就MM细胞在药物作用时其自噬活性的变化及对细胞增殖、凋亡的影响进行综述,旨在分析自噬途径在药物治疗MM中的作用,为靶向自噬治疗MM提供相关思路。Multiple myeloma(MM)is a malignant hematological tumour for which pharmacological treatments such as protease inhibitors,immunomodulators,and steroids are commonly used,but most MM cases still relapsed or become refractory.Autophagy is a type 2 cell death mechanism that plays a key role in MM progression,including biphasic regulation that promotes MM cell survival or facilitates its death.In this paper,we review the changes of MM cells'autophagic activity and its effect on cell proliferation and apoptosis during drug action,aiming to analyse the role of autophagy pathway in drug treatment of MM and provide relevant ideas for targeting autophagy in the treatment of MM.

关 键 词：多发性骨髓瘤 自噬 药物治疗 凋亡 

分 类 号：R733.3[医药卫生—肿瘤]