PBL亚型联合CTC对儿童肝母细胞瘤预后的预测价值  

Predictive value for prognosis of pediatric hepatoblastoma by combining peripheral blood lymphocyte subtypes with circulating tumor cells

作　　者：张景畅 张天佑 师文楷[1] 秦启明 赵永福[1] ZHANG Jingchang;ZHANG Tianyou;SHI Wenkai;QIN Qiming;ZHAO Yongfu(Department of Hepatobiliary and Pancreatic Surgery,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052)

机构地区：[1]郑州大学第一附属医院肝胆胰外科,郑州450052

出　　处：《郑州大学学报（医学版）》2024年第5期712-715,共4页Journal of Zhengzhou University(Medical Sciences)

摘　　要：目的:探究外周血淋巴细胞(PBL)亚型与循环肿瘤细胞(CTC)联合对儿童肝母细胞瘤(HB)术后生存的预测价值。方法:选取2018年6月至2022年6月于郑州大学第一附属医院接受肿瘤切除术的HB患儿116例,随访并记录患儿术后12个月的生存状态。采集患者术前静脉血,检测PBL亚型及CTC。采用Logistic回归构建PBL亚型联合CTC的预后预测模型。绘制ROC曲线,评价联合预测模型与单一指标对HB患儿预后的预测效能。结果:联合预测模型为Logit(P)=-20.297+0.192×CD3^(+)+1.511×CD4^(+)/CD8^(+)+0.383×CTC。CD3^(+)、CD4^(+)/CD8^(+)、CTC及联合预测模型预测HB患儿术后生存的AUC(95%CI)分别为0.634(0.488~0.780)、0.606(0.487~0.725)、0.822(0.735~0.909)、0.865(0.786~0.944),联合预测模型与单一指标相比具有更好的预测效能。结论:CTC、CD3^(+)、CD4^(+)/CD8^(+)联合预测模型可用于HB患儿术后的生存预测。Aim:To assess the value for predicting prognosis of pediatric hepatoblastoma(HB)by combining peripheral blood lymphocyte(PBL)subtypes and circulating tumor cells(CTC).Methods:A total of 116 HB children who underwent tumor resection at the First Affiliated Hospital of Zhengzhou University between June 2018 and June 2022 were included in this study.The survival status of these patients was followed up for a period of 12 months after surgery.Prior to surgery,the PBL subtypes and CTC levels in the patients′venous blood samples were determined through laboratory testing.Logistic regression was employed to construct the combined model with PBL subtypes and CDC for predicting prognosis of HB.ROC curve was drawn and the predicting value of single index and the combined model was assessed.Results:The prediction model was Logit(P)=-20.297+0.192×CD3^(+)+1.511×CD4^(+)/CD8^(+)+0.383×CTC.The AUC(95%CI)of CD3^(+),CD4^(+)/CD8^(+),CTC and combined model in predicting survival of HB children was 0.634(0.488-0.780),0.606(0.487-0.725),0.822(0.735-0.909),0.865(0.786-0.944),and the combined model had higher predictive efficacy.Conclusion:The combined model with CTC,CD3^(+),and CD4^(+)/CD8^(+)could be used for predicting survival of pediatric HB patients.

关 键 词：肝母细胞瘤 外周血淋巴细胞亚型 循环肿瘤细胞 

分 类 号：R735.7[医药卫生—肿瘤]