双相情感障碍Ⅱ型与重度抑郁障碍患者炎症细胞因子、T淋巴细胞亚群水平的比较研究  

Comparison of inflammatory cytokines and T lymphocyte subsets in patients with bipolar disorder typeⅡand major depressive disorder

作　　者：方瑜[1] 郭萍[1] 吕亮 孙桂兰 姚红芳 钱敏才[1] FANG Yu;GUO Ping;LYV Liang(Department of Psychiatry,Huzhou Third People's Hospital,Huzhou 313000,China.)

机构地区：[1]湖州市第三人民医院精神科,浙江湖州313000

出　　处：《全科医学临床与教育》2024年第9期777-780,788,共5页Clinical Education of General Practice

基　　金：浙江省基础公益研究计划项目(LGF22H090050)。

摘　　要：目的比较双相情感障碍Ⅱ型(BD-Ⅱ)与重度抑郁障碍(MDD)患者炎症细胞因子、T淋巴细胞亚群水平。方法选取40例BD-Ⅱ患者为BD-Ⅱ组,同期选取40例MDD患者为MDD组。在患者入院后24 h内,采用汉密尔顿抑郁量表(HAMD-24)、轻躁狂症状量表(HCL-32)、自杀意念自评量表(SIOSS)评估两组患者的抑郁、躁狂状态和自杀意念情况,比较两组白介素-6(IL-6)、白介素-4(IL-4)、白介素-1β(IL-1β)、CD^(3+)、CD^(4+)、CD^(8+)、CD^(4+)/CD^(8+)水平。采用Pearson相关性分析BD-Ⅱ和MDD患者炎症细胞因子、T淋巴细胞亚群计数水平与抑郁、躁狂状态和自杀意念的相关性。结果BD-Ⅱ组的HAMD-24、HCL-32、SIOSS量表得分均高于MDD组(t分别=2.20、10.00、2.71,P均<0.05)。两组血清IL-1β水平比较,差异无统计学意义(t=1.57,P>0.05)。BD-Ⅱ组的血清IL-6、IL-4水平均高于MDD组(t分别=8.88、3.60,P均<0.05)。两组CD^(4+)/CD^(8+)比较,差异无统计学意义(t=1.10,P>0.05);BD-Ⅱ组CD^(3+)、CD^(4+)、CD^(8+)水平均高于MDD组(t分别=2.83、2.64、2.68,P均<0.05)。BD-Ⅱ患者的血清IL-6、IL-4、CD^(3+)、CD^(4+)、CD^(8+)与HAMD-24、HCL-32、SIOSS量表均呈正相关(P均<0.05)。MDD患者的血清IL-6、IL-4、CD^(3+)、CD^(4+)、CD^(8+)与HAMD-24、HCL-32、SIOSS量表均呈正相关(P均<0.05)。结论相比较于MDD患者,BD-Ⅱ患者的血清IL-6、IL-4水平和CD^(3+)、CD^(4+)、CD^(8+)水平更高,与抑郁、躁狂状态和自杀意念评分具有正相关性。Objective To compare inflammatory cytokines and T lymphocyte subsets in patients with bipolar disorder typeⅡ(BD-Ⅱ)and major depressive disorder(MDD).Methods A total of 40 patients with BD-Ⅱand 40 patients with MDD were enrolled as BD-Ⅱgroup and MDD group,respectively.Within 24h after admission,depression,mania state and suicide idea of patients were evaluated by Hamilton depression scale-24(HAMD-24),hypomania checklist-32(HCL-32)and self-rating idea of suicide scale(SIOSS),respectively.The levels of IL-6,IL-4,IL-1β,CD^(3+),CD^(4+),CD^(8+),CD^(4+)/CD^(8+)between the two groups were compared.The correlation between inflammatory cytokines,T lymphocyte subsets and depression,mania state,suicide idea in the two groups was analyzed by Pearson correlation analysis.Re⁃sults The scores of HAMD-24,HCL-32 and SIOSS in BD-Ⅱgroup were higher than those in MDD group(t=2.20,10.00,2.71,P<0.05).There was no significant difference in level of serum IL-1βbetween the two groups(t=1.57,P>0.05).The levels of serum IL-6 and IL-4 in BD-Ⅱgroup were higher than those in MDD group(t=8.88,3.60,P<0.05).There was no significant difference in CD^(4+)/CD^(8+)between the two groups(t=1.10,P>0.05).The levels of CD^(3+),CD^(4+)and CD^(8+)in BD-Ⅱgroup were higher than those in MDD group(t=2.83,2.64,2.68,P<0.05).In BD-II patients,the serum levels of IL-6,IL-4,CD^(3+),CD^(4+),CD^(8+)were positively correlated with HAMD-24,HCL-32,and SIOSS scales(P<0.05).The serum levels of IL-6,IL-4,CD^(3+),CD^(4+),CD^(8+)in MDD patients were positively correlated with HAMD-24,HCL-32,and SIOSS scales(P<0.05).Conclusion Compared with MDD patients,levels of serum IL-6,IL-4,CD^(3+),CD^(4+)and CD^(8+)are higher in BD-Ⅱpatients.The above indexes are positively correlated with scores of depression,mania state and suicide idea.

关 键 词：双相情感障碍Ⅱ型 重度抑郁障碍 白介素-6 T淋巴细胞亚群 

分 类 号：R749.4[医药卫生—神经病学与精神病学]