Innovative hydrogel-based delivery systems for immunotherapy:A review of pre-clinical progress  

作　　者：Narsimha Mamidi Michael Poellmann Kaila Javius-Jones KiChang Nam Seungpyo Hong 

机构地区：[1]Wisconsin Center for NanoBioSystems,University of Wisconsin-Madison,Madison,WI 53705,USA [2]Pharmaceutical Sciences Division,School of Pharmacy,University of Wisconsin-Madison,Madison,WI 53705,USA [3]Department of Medical Engineering,College of Medicine,Dongguk University,Goyang 10326,Republic of Korea [4]Department of Pharmacy,Yonsei University,Incheon 21983,Republic of Korea [5]Lachman Institute for Pharmaceutical Development,University of Wisconsin-Madison,Madison,WI 53705,USA

出　　处：《Nano Research》2024年第10期9031-9043,共13页纳米研究（英文版）

基　　金：partially supported by the National Science Foundation(NSF)(No.DMR-2211932);the National Institutes of Health(NIH)(Nos.P50CA278595 and 1R01CA262292);supported by Falk Medical Research Trust(Transformational Award);Dongkook Pharmaceuticals via an Industry Sponsored Research Agreement(SRA);Milton J.Henrichs Chair fund.

摘　　要：Immunotherapy has markedly reinvented how we treat cancer,as shown by numerous Food and Drug Administration(FDA)drug approvals that have made significant clinical impact and ongoing clinical trials.However,undesirable side effects,such as autoimmunity and inflammation,and inconsistent clinical outcomes remain a major challenge.Improving response rates across various immunotherapeutic reagents is imperative to enhance overall effectiveness and reduce adverse side effects.To address this challenge,interdisciplinary approaches have been explored by incorporating immunotherapies into hydrogels,enabling finecontrolled delivery to target tissues.This review focuses on recent progress in the utilization of hydrogel-based delivery systems for cancer immunotherapy and their potential to further enhance treatment response rates.Specifically,recent preclinical advances in hydrogels implemented with immune checkpoint inhibitors,combination therapies,and vaccines,along with selfassembled peptide hydrogels,are reviewed.We also discuss technological advances and drawbacks in this area and provide insights to ultimately realize the clinical application of hydrogels in cancer immunotherapy.

关 键 词：cancer immunotherapy drug delivery HYDROGELS immunotherapeutic agents immune modulation clinical outcomes 

分 类 号：R730.51[医药卫生—肿瘤]