Lipocoacervate,a tunable vesicle for protein delivery  

作　　者：Chia-Wei Yeh Nathaniel Wright Chelsea Loh Nabeen Chu Yadong Wang 

机构地区：[1]Nancy E.and Peter C.Meinig School of Biomedical Engineering,Cornell University,Kimball Hall 290,Ithaca 14853,USA [2]Human Biology,Health,and Society.College of Human Ecology,Cornell University,Ithaca 14853,USA

出　　处：《Nano Research》2024年第10期9135-9140,共6页纳米研究（英文版）

摘　　要：Controlled delivery of proteins and other biologics is a growing medium of therapy for diseases previously untreatable.Here we report a self-assembling,tunable vesicle for the controlled delivery of growth factors and cytokines.Coacervate made of heparin and a biocompatible polycation,PEAD,forms the core of the vesicle;lipids form the membrane of the vesicle.We call this vesicle lipocoacervate(LipCo),which has a high affinity for growth factors and cytokines due to heparin.LipCo is a tunable protein delivery vehicle.The vesicle size is controlled through polymer and salt concentrations.Membrane functionalization enables potential for targeting capabilities with long-term storage through lyophilization.Importantly,the controlled delivery of therapeutics also avoids high toxicity to treated cells in vitro.Here we report on these key principles of LipCo assembly and design.

关 键 词：complex coacervate drug delivery protein delivery HEPARIN lipid particle 

分 类 号：Q51[生物学—生物化学]