细胞焦亡在认知功能障碍中的研究进展  

Research Progress of Pyroptosis in Cognitive Impairment

作　　者：张超[1] 王晓冬[2] 王莹[2] 邱颐[2] ZHANG Chao;WANG Xiaodong;WANG Ying;QIU Yi(Graduate School of Inner Mongolia Medical University,Hohhot 010000,China;Anesthesia Surgery Center,the Second Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010000,China)

机构地区：[1]内蒙古医科大学研究生院,呼和浩特010000 [2]内蒙古医科大学第二附属医院麻醉手术中心,呼和浩特010000

出　　处：《医学综述》2024年第20期2470-2476,共7页Medical Recapitulate

基　　金：国家自然科学基金(82160221);内蒙古医科大学科技创新团队(YKD2022TD032);内蒙古医科大学面上项目(YKD2023MS009)。

摘　　要：随着我国人口老龄化程度加剧,认知功能障碍患者逐渐增加,同时也伴随术后并发症的增加以及老年患者生活质量的降低。目前细胞焦亡已成为认知功能障碍发病机制研究的热点,炎症小体、胱天蛋白酶、消皮素D作为细胞焦亡的重要组成部分,可通过抑制与其相关的细胞信号转导、关键蛋白的合成、配体的激活组装等,有效降低细胞焦亡水平,缓解认知功能障碍。因此,未来深入研究细胞焦亡在认知功能障碍中的作用机制,可以为疾病的治疗提供新思路。The proportion of patients with cognitive impairment is gradually increasing in the context of the aging population in our country,which is accompanied by a rise in postoperative complications and a decrease in the quality of life for the elderly patients.Currently,cellular pyroptosis has become a hot topic in the study of the pathogenesis of cognitive dysfunction.Inflammasomes,caspases,and gasdermin D are important components of pyroptosis,and by inhibiting the associa-ted signaling pathways,synthesis of key proteins and activation and assembly of ligands,it is possible to effectively reduce the level of pyroptosis and alleviate the cognitive impairment.Therefore,in-depth research on the mechanism of pyroptosis in cognitive impairment in the future can provide new ideas for the treatment of the diseases.

关 键 词：认知功能障碍 细胞焦亡 炎症小体 胱天蛋白酶 消皮素D 

分 类 号：R741[医药卫生—神经病学与精神病学]