TCT检查联合高危型HPV检测在宫颈癌筛查中的应用效果  

Application of Thinprep cytology test combined with high-risk human papilloma virus detection for screening cervical cancer

作　　者：于映红 胡婕 刘玉兰 陈仕高 谭志巍 程双华 YU Yinghong;HU Jie;LIU Yulan;CHEN Shigao;TAN Zhiwei;CHENG Shuanghua(The Second Affiliated Hospital of Chengdu Medical College(China National Nuclear Corporation 416 Hospital),Chengdu,Sichuan Province,610057)

机构地区：[1]成都医学院第二附属医院,核工业四一六医院,610057

出　　处：《中国计划生育学杂志》2024年第9期2161-2164,共4页Chinese Journal of Family Planning

摘　　要：目的:探究宫颈液基细胞学(TCT)检查联合高危型人乳头瘤病毒(HR-HPV)检测在宫颈癌筛查中的应用效果。方法:收集2022年1月-2023年5月本院行宫颈癌筛查的3500例临床资料,以病理学诊断为金标准,采用受试者工作特征(ROC)曲线分析TCT、HR-HPV检查及两者联合对宫颈癌的筛查效能。结果:3500例中病理诊断宫颈癌33例,余112例为CINⅡ+Ⅲ、267例为CINⅠ、3088例为宫颈炎。ROC曲线分析,TCT筛查宫颈癌的曲线下面积(AUC)为0.741,敏感度48.5%、特异度99.7%;HR-HPV检测筛查宫颈癌的AUC为0.769,敏感度54.6%、特异度99.3%;TCT联合HR-HPV筛查(即其中任意一项为阳性即可诊断为宫颈癌阳性)宫颈癌的AUC为0.980,敏感度97.0%、特异度99.1%。结论:TCT联合HR-HPV检测具备较高诊断效能,可提升宫颈癌筛查的敏感度,用于宫颈癌及癌前病变的临床筛查有较高临床价值。Objective:To investigate the application effect of Thinprep cytology test(TCT)combined with high-risk human papillomavirus(HR-HPV)detection for screening cervical cancer.Methods:The clinical data of 3,500 women who received cervical cancer screening from January 2022 to May 2023 were selected as the study subjects.With the pathological diagnosis as the gold standard,the diagnostic efficacy of TCT,HR-HPV detection,and the combination of TCT and HR-HPV detection of the women for their cervical cancer was analyzed by receiver operating characteristic(ROC)curve.Results:Among 3500 women,there were 33 cases with cervical cancer,112 cases with cervical intraepithelial neoplasia(CIN)II and CINI II,267 cases with CIN I and 3,088 cases with cervicitis.ROC curve analysis results showed that the area under the curve(AUC)of the TCT of the women for screening their cervical cancer was 0.741,with the sensitivity of 48.5%and the specificity of 99.7%.The AUC of the HR-HPV detection of the women for screening their cervical cancer was 0.769,with the sensitivity of 54.6%and the specificity of 99.3%.When the women diagnosed as cervical cancer based on the TCT or the HR-HPV detection with positive result,the AUC of the TCT combined with the HR-HPV detection of the women for screening their cervical cancer was 0.980,with the sensitivity of 97.0%and the specificity of 99.1%.Conclusion:TCT combined with HR-PHV detection of the women for screening their cervical cancer has higher diagnostic efficacy,which can improve the diagnostic sensitivity and has higher clinical value for screening the cervical cancer and the precancerous lesions of the women.

关 键 词：宫颈癌 宫颈液基细胞学 高危型人乳头瘤病毒 联合筛查 效能 敏感度 

分 类 号：R737.33[医药卫生—肿瘤]