硫普罗宁与甘草酸二铵肠溶胶囊联合治疗非酒精性脂肪肝的临床疗效及不良反应分析  

Clinical efficacy and adverse reactions analysis of the combination therapy of tiopronin and glycyrrhizic acid diammonium enteric coated capsules for non-alcoholic fatty liver disease

作　　者：程艳洁 李峻[1] 王鹏飞 Cheng Yanjie;Li Jun;Wang Pengfei(Department of Gastroenterology,Nanping First Hospital of Fujian,Nanping,Fujian 353000,China)

机构地区：[1]福建省南平市第一医院消化内科,福建南平353000

出　　处：《感染、炎症、修复》2023年第2期63-66,共4页Infection Inflammation Repair

基　　金：福建医科大学启航基金项目(2020QH1308)。

摘　　要：目的:分析采用硫普罗宁联合甘草酸二铵肠溶胶囊治疗非酒精性脂肪肝(NAFLD)的临床疗效及不良反应。方法:选取2021年9月至2023年1月福建省南平市第一医院收治的NAFLD患者60例为研究对象,随机红蓝球分组方式将患者分为对照组(硫普罗宁治疗)与观察组(硫普罗宁联合甘草酸二铵肠溶胶囊治疗),每组30例,比较两组肝功能水平[谷氨酰转移酶(GGT)、丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)]、肝纤维化水平[血清层粘连蛋白(LN)、血清透明质酸(HA)、血清Ⅲ型前胶原(PCⅢ)、血清Ⅳ型胶原(Ⅳ-C)]、血脂水平[低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)、总胆固醇(TC)]、临床疗效、用药不良反应发生率。结果:治疗后两组AST、ALT、GGT、HA、LN、Ⅳ-C、PCⅢ、TC、LDL-C、TG水平均下降,且观察组低于对照组(P<0.05)。治疗后观察组总有效率高于对照组(93.33%比73.33%;χ2=4.320,P<0.05)。两组不良反应发生率(0比6.67%)比较差异无统计学意义(χ2=2.069,P>0.05)。结论:联合使用硫普罗宁与甘草酸二铵肠溶胶囊是治疗NAFLD的有效方法,能够显著促进肝脏功能的修复,并有效减轻肝纤维化和血脂异常,且用药安全性高。Objective:To analyze the clinical efficacy and adverse reactions of treating Non-alcoholic fatty liver disease(NAFLD)with thioprine combined with glycyrrhizic acid diammonium enteric coated capsules.Methods:Sixty NAFLD patients from September 2021 to January 2023 admitted to Nanping First Hospital of Fujian were selected as the study subjects.The patients were randomly divided into the control group(treated with tiopronin)and the observation group(tiopronin combined with glycyrrhizic acid diammonium enteric coated capsules)by the red and blue ball grouping method,with 30 cases in each group.The liver function levels such as glutamyltransferase(GGT),alanine aminotransferase(ALT),aspartate aminotransferase(AST),liver fibrosis levels such as serum laminin(LN),serum hyaluronic acid(HA),serum typeⅢprocollagen(PCⅢ),serum typeⅣcollagen(Ⅳ-C),blood lipid levels such as low density lipoprotein cholesterol(LDL-C),triglyceride(TG),total cholesterol(TC),clinical efficacy,and incidence of adverse drug reactions were compared between the two groups.Results:After treatment,the levels of AST,ALT,GGT,HA,LN,Ⅳ-C,PCⅢ,TC,LDL-C,and TG in both groups decreased,and the observation group was lower than the control group(P<0.05).After treatment,the total effective rate of the observation group was higher than that of the control group(93.33%vs 73.33%;χ2=4.320,P<0.05).There was no difference in the incidence of adverse reactions(0 vs 6.67%)between the two groups(χ2=2.069,P>0.05).Conclusions:The combined use of tiopronin and diammonium glycyrrhizinate enteric-coated capsules is an effective treatment for NAFLD,significantly promoting liver function recovery,effectively alleviating liver fibrosis and dyslipidemia,and exhibiting high medication safety.

关 键 词：硫普罗宁 甘草酸二铵肠溶胶囊 非酒精性脂肪肝 不良反应 

分 类 号：R57[医药卫生—消化系统] R575.5[医药卫生—内科学]