全程营养支持治疗对局部晚期宫颈癌放化疗疗效及PG-SGA评分的影响研究  

Effect of whole-course nutritional support therapy on curative effect and PG-SGA score in patients with local advanced cervical cancer treated with radiotherapy and chemotherapy

作　　者：崔杨 金洋 王瑞景 李秀杰 CUI Yang;JIN Yang;WANG Rui-jing;LI Xiu-jie(Department of Gunaecology,Affiliated Cancer Hospital of Zhengzhou University,Henan Cancer Hospital,Zhengzhou 450000,China)

机构地区：[1]郑州大学附属肿瘤医院,河南省肿瘤医院妇科七病区,郑州450000

出　　处：《医药论坛杂志》2024年第14期1480-1483,共4页Journal of Medical Forum

基　　金：河南省医学科技攻关计划联合共建项目(LHGJ20190653)。

摘　　要：目的分析局部晚期宫颈癌(locally advanced cervical cancer,LACC)放化疗患者接受全程营养支持治疗的疗效及对整体营养状况评估量表(patient generated subjective global assessment,PG-SGA)评分的影响。方法选取2020年6至2022年12月郑州大学附属肿瘤医院收治的112例局部晚期宫颈癌患者,按照是否进行营养支持治疗分组,将单纯进行同步放化疗的56例作为基础组,将同步放化疗基础上加以全程营养支持治疗的56例作为研究组,比较两组疗效、耐受性以及放射反应。结果研究组临床干预有效率89.28%,高于基础组的64.28%(P<0.05);研究组中断率及放疗总天数分别为17.85%和(62.31±7.46)d,均少于基础组,化疗完成次数(4.98±0.51)次,高于基础组,差异均有统计学意义(P<0.05);研究组的血小板降低、急性胃肠道反应和放射性膀胱炎总发生率分别为21.42%、25.00%和28.57%,均低于基础组(P<0.05);研究组干预之后的营养状况PG-SGA评分(5.13±0.44)分,低于基础组(P<0.05)。结论LACC患者放化疗期间采用全程营养支持治疗,不仅能够促进疗效、治疗依从性以及显著提升生活质量,同时还能降低急性放射反应,确保放疗能够按照计划完成,具有显著的临床应用价值,值得推广。Objective To analyze the effects of whole-course nutritional support therapy on acute radiation response,tolerance and curative effect in patients with cervical cancer.Methods Totally 112 patients with locally advanced cervical cancer admitted to Affiliated Cancer Hospital of Zhengzhou University from June 2020 to December 2022 were selected and divided into groups according to whether they received nutritional support therapy or not.56 cases receiving simultaneous chemoradiotherapy alone were taken as the basic group,and 56 cases receiving full nutritional support therapy on the basis of simultaneous chemoradiotherapy were taken as the study group.The efficacy,tolerance and radiation response of the two groups were compared.Results The effective rate of clinical intervention in the research group was 89.28%,which was higher than 64.28% in the basic group(P<0.05);the interruption rate and the total days of radiotherapy in the study group were 17.85%and(62.31±7.46)d,respectively,lower than that in the basic group,and the number of chemotherapy completion times was(4.98±0.51),higher than that in the basic group,with statistical significance(P<0.05).The total incidence of thrombocytopenia,acute gastrointestinal reaction and acute radiation cystitis in the study group was 21.42%,25.00% and 28.57%,respectively,which were lower than those in the basic group(P<0.05).The PG-SGA score of the study group after intervention was 5.13±0.44,which was lower than that of the basic group(P<0.05).Conclusion The use of whole-course nutritional support therapy during chemotherapy and radiotherapy in patients with LACC can not only reduce the acute radiation reaction of patients,but also significantly improve the efficacy,treatment compliance and quality of life,and ensure that radiotherapy can be completed according to the plan,which has significant clinical application value and is worth promoting.

关 键 词：全程营养支持 宫颈癌 急性放射反应 耐受性 

分 类 号：R737.33[医药卫生—肿瘤]