基于蛋白质组学中药药性理论的研究进展及展望  

Research progress and prospects of traditional Chinese medicine efficacy theory based on proteomics

作　　者：尹建宇 张丽敏 张淼[1] 隋方宇[1] 关子赫 代巧妹[1] 旺建伟[1] YIN Jianyu;ZHANG Limin;ZHANG Miao;SUI Fangyu;GUAN Zihe;DAI Qiaomei;WANG Jianwei(Heilongjiang University of Chinese Medicine,Harbin 150040,China)

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040

出　　处：《中草药》2024年第16期5669-5677,共9页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(81573870);中国博士后科学基金第八批特别资助项目(2015T80376);国家中医药管理局第五批全国中医临床优秀人才研修项目(国中医药人教函[2022]239号);全国中医药创新骨干人才培养项目(国中医药人教函[2019]128号)。

摘　　要：蛋白质组学是一门关注细胞动态变化和整体联系的现代科学,通过对特定蛋白质组进行大规模全面的研究,可以深入了解生命系统的内在机制。这种重视联系、动态和整体的研究思路与中药药性理论的指导思想和科学内涵高度相符。因此,在中药药性研究中应用蛋白质组学技术,不仅能为中药药性理论的现代科学认识提供新的思路和方法,同时也有助于推进中医药理论的守正清源,创新发展。通过对蛋白质组学的研究内容及其与中医整体观的联系进行简要概述,着重从中药药性理论溯源及蛋白组学的角度对中药药性理论的内容,包括四气、归经、毒性、配伍等的现代化研究进行综述,为相关研究中的应用提供参考。Proteomics is a modern science that focuses on cellular dynamics and overall connections.Large-scale and comprehensive studies of specific proteomes can provide insight into the inner workings of living systems.Since this research idea of attaching importance to connection,dynamics and wholeness is highly consistent with the guiding ideology and scientific connotation of the theory of medicinal properties of traditional Chinese medicine(TCM),the application of proteomics technology in the study of medicinal properties of TCM can not only provide new ideas and methods for the modern scientific understanding of the medicinal properties of TCM,but also help to promote the integrity and innovative development of TCM theory.This paper briefly summarizes the research content of proteomics and its relationship with the holistic view of TCM,and focuses on the modern research on the content of the theory of medicinal properties of TCM from the perspective of tracing the origin of the medicinal properties of TCM and proteomics,including the four qi,meridians,toxicity,compatibility,etc.,which can provide a reference for the application of related research.

关 键 词：蛋白质组学 中药药性理论 四气 归经 毒性 配伍 

分 类 号：R28[医药卫生—中药学]