L-茶氨酸对大鼠固有免疫功能的调节作用  

Regulation of L-Theanine on Innate Immune Function in Rats

作　　者：李成舰 孙兿薴 郭俊涵 赵金诚 刘紫依 麦芷瑞 梅宇琛 王译章 LI Chengjian;SUN Yining;GUO Junhan;ZHAO Jincheng;LIU Ziyi;MAI Zhirui;MEI Yuchen;WANG Yizhang(School of Pharmacy,Shaoyang University,Shaoyang 422000,China;Southwest Hunan Research Center of Engineering for Development and Utilization of Traditional Chinese Medicine,Shaoyang 422000,China)

机构地区：[1]邵阳学院药学院,湖南邵阳422000 [2]湘西南中药开发利用湖南省工程研究中心,湖南邵阳422000

出　　处：《生物化工》2024年第4期101-103,108,共4页Biological Chemical Engineering

基　　金：湖南省自然科学基金(2022JJ50026);湖南省普通高等学校科技创新团队支持项目(湘教通[2023]233号)。

摘　　要：目的:通过探究L-茶氨酸调节大鼠固有免疫功能的作用,为开发以L-茶氨酸为主要成分的新型食品添加剂的推广应用奠定基础。方法:通过单因素多组间对比,研究L-茶氨酸处理对大鼠免疫器官指数、血液中免疫球蛋白、固有淋巴细胞的增殖及其细胞因子分泌的影响。结果:L-茶氨酸通过促进脾脏发育,增加免疫球蛋白G(IgG)的分泌;促进固有淋巴细胞1(ILC1)与淋巴组织诱导细胞(LTi)增殖,促进白介素-4(IL-4)的分泌。结论:L-茶氨酸可以增强大鼠固有免疫功能,可为以L-茶氨酸为主要成分的新型食品添加剂开发及其推广应用提供依据。Objective:Through exploring the effect of L-theanine on the regulation of innate immune function in rats,this paper lays a foundation for the development of new food additives based on L-theanine as the main component.Methods:The effects of L-theanine treatment on immune organ index,immunoglobulin,lymphocyte proliferation and cytokine secretion in blood of rats are studied by comparing the factors among different groups.Results:L-theanine increases immunoglobulin G(IgG) secretion by promoting spleen development;promote intrinsic lymphocytes 1(ILC1) and lymphoid tissue induces cells(LTi) proliferation,promote interleukin-4(IL-4) secretion.Conclusion:L-theanine treatment can enhance the innate immune function in rats,and provide basis for the development and application of L-theanine as the main component of new food additive.

关 键 词：L-茶氨酸 大鼠 固有免疫功能 新型食品添加剂 

分 类 号：R392.5[医药卫生—免疫学]