抗氧化和促氧化机制在抗肿瘤治疗中的相似性与差异性  

Similarities and Differences of Antioxidant and Pro-Oxidant Mechanisms Against Tumor

作　　者：陈嘉逸 张芸 侯俊玲[1] 梅婷 CHEN Jiayi;ZHANG Yun;HOU Junling;MEI Ting(College of Traditional Chinese Medicine,Beijing University of Chinese Medicine,Beijing 102488,China)

机构地区：[1]北京中医药大学中药学院,北京102488

出　　处：《生物化工》2024年第4期218-221,226,共5页Biological Chemical Engineering

基　　金：2022年国家自然科学青年基金(82204635);2021年度北京中医药大学教育科学研究课题(JY21024);2020年北京中医药大学“侯俊玲教学名师工作坊”项目(MSGZF-202001)。

摘　　要：活性氧(Reactive Oxygen Species,ROS)和氧化应激是肿瘤发生和发展的关键因素。低水平的ROS可以刺激肿瘤细胞的增殖和存活,过量的ROS会导致细胞损伤和凋亡。因此,ROS调节已成为一种有前景的癌症治疗策略。本文对抗氧化剂和促氧化剂的抗肿瘤机制进行了研究和比较,旨在为抗癌药物开发和癌症治疗策略的开发提供新的见解和思路。Reactive oxygen species(ROS) and oxidative stress are key factors in the development and progression of tumors.Low levels of ROS can stimulate tumor cells proliferation and survival,while excessive ROS can cause cell damage and apoptosis.As a result,the regulation of ROS has become a promising therapeutic strategy for cancer treatment.This review examines and compares the anti-tumor mechanisms of antioxidants and pro-oxidants,with the aims to provide new insights and ideas for the development of anti-cancer drugs and cancer treatment strategies.

关 键 词：活性氧 氧化应激 抗肿瘤 促氧化治疗 

分 类 号：R730.5[医药卫生—肿瘤]