羟基红花黄色素A对自发性高血压大鼠肾损伤的保护作用  

Protective effect of hydroxysafflor yellow A against renal injuryin spontaneously hypertensive rats

作　　者：杨一 刘京 孙巍[2] 赵静岩[2] 张敏 邓祎婕 谷博 杨玉莹 王仁俊[1] 刘海峰[2] YANG Yi;LIU Jing;SUN Wei;ZHAO Jing-yan;ZHANG Min;DENG Yi-jie;GU Bo;YANG Yu-ying;WANG Ren-jun;LIU Hai-feng(College of Life Sciences,Jilin Normal University,Siping 136000,China;Siping Central People's Hospital,Siping 136000,China)

机构地区：[1]吉林师范大学生命科学学院,吉林四平136000 [2]四平市中心人民医院,吉林四平136000

出　　处：《东北师大学报（自然科学版）》2024年第3期104-110,共7页Journal of Northeast Normal University(Natural Science Edition)

基　　金：国家自然科学基金资助项目(31871150);吉林省科技发展计划项目(YDZJ 202201ZYTS457,YDZJ 202201ZYTS433,20220101322JC).

摘　　要：采用生化检测、HE染色和免疫组化技术,研究了羟基红花黄色素A(Hydroxysafflor yellow A,HSYA)对自发性高血压大鼠(Spontaneously hypertensive rat,SHR)血清生化、氧化应激和肾脏病理的影响.结果表明:与SHR模型组相比,不同剂量HSYA可调节SHR的血清REN、AngⅡ、ALD、ACE、TNF-α和IL-6含量,提高肾组织中SOD、GSH-Px活性,降低MDA含量,上调HMGCS2蛋白表达,改善肾脏病理程度.The effects of hydroxysafflor yellow A(HSYA)on serum biochemistry,oxidative stress and renal pathology in spontaneously hypertensive rat(SHR)were investigated using biochemical assays,HE staining and immunohistochemical techniques.The results showed that compared with the SHR model group,different doses of HSYA could regulate the serum REN,AngⅡ,ALD,ACE,TNF-αand IL-6 levels,increase the SOD and GSH-Px activities in renal tissues,decrease the MDA content,up-regulate the expression of HMGCS2 proteins,and improve the degree of renal pathology in SHR.The study also further provides a theoretical basis and experimental reference for the clinical application of HSYA in the treatment of renal injury in essential hypertension.

关 键 词：羟基红花黄色素A 自发性高血压 肾损伤 HMGCS2 抗氧化 

分 类 号：R363.2[医药卫生—病理学]