羧甲基壳聚糖脱乙酰度和取代度检测技术综述  

Review on the Deacetylation Degree and Substitution Degree of Carboxymethyl Chitosan

作　　者：郭采妮 刘璟 丁黎[2] 付步芳[1] Guo Caini;Liu Jing;Ding Li;Fu Bufang(National Institutes for Food and Drug Control,Beijing 102629,China;China Pharmaceutical University,Nanjing 211198,China)

机构地区：[1]中国食品药品检定研究院,北京102629 [2]中国药科大学,江苏南京211198

出　　处：《广东化工》2024年第18期79-81,103,共4页Guangdong Chemical Industry

基　　金：国家重点研发计划项目(2017YFC1105000)。

摘　　要：随着羧甲基壳聚糖作为生物材料在医疗器械行业中被广泛应用,迫切地需要能够有效测定其脱乙酰度和取代度的方法。与此同时,存在着羧甲基壳聚糖脱乙酰度和取代度的检测技术不完善,检测方法欠缺等问题。因此,该文简述了灰分分析法、胶体滴定法、核磁共振法、傅里叶变换红外光谱法、电位滴定法、电导滴定法、顶空气相色谱法检测羧甲基壳聚糖脱乙酰度和取代度的原理、方法,分析讨论了各方法的优缺点。最后,展望顶空气相色谱检测技术对羧甲基壳聚糖的脱乙酰度和取代度的研究前景,随着该方法研究的深入和广泛开展,可以进一步促进羧甲基壳聚糖质量评价技术的发展。With the wide application of CMCS(carboxymethyl chitosan)as biomaterials in the medical instrumentation industry,it is urgently needed for get an effective method to determine DD(the degree of deacetylation)and DS(degree of substitution).At the same time,there are problems such as incomplete detection techniques for the DD and DS of CMCS,and insufficient detection methods.Therefore,this article briefly described the principles and methods of ash analysis,colloidal titration,NMR,FT-IR,potentiometric titration,conductance titration,HS-GC,analyzed and discussed the advantages and disadvantages of each method.Finally,the study prospect of DD and DS values of CMCS by HS-GC is prospected.With the in-depth and extensive development of this method,it can further promote the development of quality evaluation technology for CMCS.

关 键 词：羧甲基壳聚糖 脱乙酰度 取代度 顶空气相色谱 

分 类 号：O657[理学—分析化学] O656.3[理学—化学]