黄毛榕中具有α-葡萄糖苷酶抑制活性化合物的研究  

Study on the compounds withα-glucosidase inhibitory activity from leaves of Ficus esquiroliana

作　　者：代德财 张笑笑 徐晓娟 李子昂 董凌嫣 陈青霞 张蕊 DAI De-cai;ZHANG Xiao-xiao;XU Xiao-juan;LI Zi-ang;DONG Ling-yan;CHEN Qing-xia;ZHANG Rui(College of Chemistry and Materials Engineering,Hainan Vocational University of Science and Technology,Haikou 571126,China)

机构地区：[1]海南科技职业大学化学与材料工程学院,海口571126

出　　处：《天然产物研究与开发》2024年第9期1537-1541,1518,共6页Natural Product Research and Development

基　　金：国家级大学生创新训练项目(14172);海南省大学生创新训练项目(S202114172029)。

摘　　要：为研究黄毛榕叶中具有降糖活性的成分,综合运用硅胶柱色谱、ODS柱色谱、Sephadex LH-20凝胶柱色谱以及半制备高效液相色谱法从黄毛榕95%的乙醇浸提物中共分离得到9个化合物,并通过核磁共振(NMR)、高分辨质谱(HR-ESI-MS)等技术鉴定了这9个化合物的结构,分别为N-阿魏烷基-L-脯氨酸甲酯(1)、N-反式-对香豆酰酪胺(2)、3′,4′,5′-三甲氧基肉桂醇(3)、lcariside H1(4)、(-)-dendrolactone(5)、3-羟基-1-(4-羟基-3,5-二甲氧基苯基)-1-丙酮(6)、反式阿魏酸(7)、4′-羟基-3′,5′-二甲氧基肉桂醇(8)和对羟基反式肉桂酸(9),化合物1为新化合物,化合物2~6和8首次从黄毛榕中分离得到。α-葡萄糖苷酶抑制活性测试结果表明得到的苯丙素类化合物1~6和8显示一定的α-葡萄糖苷酶抑制活性,IC50值范围为76.25~263.18μmol/L。This study aims to investigate the chemical constituents from the leaves Ficus equiroliana H.Lév,together with theirα-glucosidase inhibitory activities.Nine compounds were isolated and purified from the 95%ethanol extract of the title plant by using systematic separation methods,including silica gel,ODS,Sephadex LH-20 column chromatography and semi-preparative liquid chromatography.Their structures were identified as N-trans-ferulic-L-proline methyl ester(1),N-p-coumaroyltyramine(2),3′,4′,5′-trimethoxycinnamyl alcohol(3),lcariside H 1(4),(-)-dendrolactone(5),3-hydroxy-1-(4-hydroxy-3,5-dimethoxyphenyl)-1-propanone(6),trans-ferulic acid(7),sinapyl alcohol(8)and(E)-p-coumaric acid(9)by NMR and HR-ESI-MS.Compound 1 is a new compound,compounds 2-6 and 8 were isolated for the first time from the leaves of F.equiroliana.Compounds 1-6 and 8 showedα-glucosidase inhibitory activities with IC 50 values of 76.25-263.18μmol/L.

关 键 词：黄毛榕 化学成分 苯丙素 Α-葡萄糖苷酶 

分 类 号：R284.2[医药卫生—中药学]