医源性脑淀粉样血管病的研究进展  

Recent advances in iatrogenic cerebral amyloid angiopathy

作　　者：颜庭梦 徐佳洁 董强 程忻 Tingmeng Yan;Jiajie Xu;Qiang Dong;Xin Cheng(Department of Neurology,Huashan Hospital,Fudan University,Shanghai 200040,China)

机构地区：[1]复旦大学附属华山医院神经内科,上海200040

出　　处：《中华脑血管病杂志（电子版）》2024年第4期370-374,共5页Chinese Journal of Cerebrovascular Diseases(Electronic Edition)

基　　金：上海市卫生健康委员会卫生健康学科带头人计划项目(2022XD022)。

摘　　要：医源性脑淀粉样血管病(iCAA)是由既往医疗操作引发的脑小血管病,常表现为青年人群的自发性脑叶出血。目前临床医师对这一新兴概念尚缺乏认识,同时该病的医源性暴露途径及背后机制尚不明确。明确医源性暴露途径不仅有助于诊断,而且对散发性淀粉样血管病的发病机制将有所启迪,也可能影响脑出血患者的手术决策。因此,笔者查阅文献,追溯最早的相关病例,对不同医源性暴露途径、临床影像表现及预后进行综述,并探讨未来可能的研究方向。Iatrogenic cerebral amyloid angiopathy(iCAA)is a small vessel disease caused by previous medical procedures,typically manifesting as spontaneous lobar hemorrhage,primarily among the middle-aged population.However,this emerging concept has not been fully recognized by most clinicians,along with the exposure sources and underlying mechanism.Clarifying these issues not only aids in diagnosis,but also provides insights into the pathogenesis of sporadic CAA.Besides,it might facilitate decision-making for those CAA-related hemorrhage patients.Therefore,we reviewed the literature,traced the earliest cases,and summarized the different exposure sources and clinical features of iCAA.

关 键 词：医源性脑淀粉样血管病 β淀粉样蛋白传播 朊蛋白 

分 类 号：R743.3[医药卫生—神经病学与精神病学]