前驱期多系统萎缩的研究进展  

Research progress on prodromal multiple system atrophy

作　　者：潘竞[1] 康佳 王新 海日罕 陈彪[2] Pan Jing;Kang Jia;Wang Xin;Hai Rihan;Chan Piu(Department of Neurology,the Second Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010010;Departments of Neurobiology,Neurology and Geriatrics,Xuanwu Hospital of Capital Medical University,Beijing 100053,China)

机构地区：[1]内蒙古医科大学第二附属医院神经内科,呼和浩特010010 [2]首都医科大学宣武医院神经生物室/神经内科/老年医学,北京100053

出　　处：《中华老年医学杂志》2024年第9期1191-1195,共5页Chinese Journal of Geriatrics

基　　金：国家重点研发计划(2021YFC2501200、2018YFC1312001、2017YFC0840105,2017YFC1310200);内蒙古自然科学基金(2020MS08138);内蒙古自治区医疗卫生科技计划项目(202202216);内蒙古医科大学项目(YKD2022LH024、YKD2023XK008)。

摘　　要：多系统萎缩(MSA)是一种进展迅速的神经系统退行性疾病,和帕金森病(PD)、路易体痴呆(DLB)同属于α-突触核蛋白病。由于同类疾病早期临床症状的重叠以及目前诊断标准对疾病早期缺乏敏感性,开展疾病早期修饰治疗药物的临床试验困难重重,疾病修饰治疗药物的研发以及诊断工具的开发和验证进展缓慢。因此,国际运动障碍协会(MDS)开发了新的MSA诊断标准,首次提出可能的前驱期MSA的定义和诊断标准。本综述介绍了可能的前驱期MSA诊断标准以及与其他前驱期α-突触核蛋白病鉴别诊断,以提高疾病在早期阶段诊断的准确性,有利于疾病早期研究的开展。Multiple system atrophy(MSA)is a rapidly progressive neurodegenerative disease and,along with Parkinson's disease(PD)and dementia with Lewy bodies(DLB),belongs to the group ofα-synucleinopathies.Due to an overlap of clinical symptoms of similar diseases in the early stages and a lack of sensitivity of the current diagnostic criteria to detect the disease in the early stages,difficulties abound in conducting clinical trials on disease-modifying therapeutic agents for its early treatment,and progress in the development of disease-modifying therapeutic agents as well as the development and validation of diagnostic tools has been slow.Consequently,the International Movement Disorder Society(MDS)has introduced new diagnostic criteria for MSA,which,for the first time,propose a category known as possible prodromal MSA and its diagnostic criteria.This review described the diagnostic criteria for possible prodromal MSA and its differential diagnosis from other prodromalα-synucleinopathies,in order to improve the accuracy of diagnosis in the early stages and to promote research on the early stages of the disease.

关 键 词：多系统萎缩 Α突触核蛋白 诊断 鉴别 

分 类 号：R741[医药卫生—神经病学与精神病学]