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作 者:吕大娇 王倩[1] 郑春玲[1] 郭乐乐 黄圣明[1] Lu Dajiao;Wang Qian;Zheng Chunling;Guo Lele;Huang Shengming(Luohe Chentral Hospital,Luohe,Henan 462000)
出 处:《辽宁医学杂志》2024年第4期13-16,共4页Medical Journal of Liaoning
基 金:河南省医学科技攻关计划(联合共建)项目编号:LHGJ20191412。
摘 要:目的探究左乙拉西坦联合丙戊酸钠改善成人癫痫患者骨代谢及减少脑电图棘波的作用效果。方法收集漯河市中心医院神经内科2019年5月至2020年5月收治的78例成人癫痫患者病例资料,对其治疗情况展开回顾性研究,以单独口服丙戊酸钠患者为A组(n=39例),以联合口服左乙拉西坦、丙戊酸钠患者为B组(n=39例),为期2个疗程,对比临床疗效。结果用药2个疗程后,B组总有效率94.87%较A组74.36%高(P<0.05);B组I型胶原N端前肽、25羟基维生素D_(3)水平较A组高(P<0.05);B组脑电图棘波少于A组(P<0.05);两组不良反应比较差异无统计学意义(P>0.05)。结论左乙拉西坦联合丙戊酸钠的整体效果较理想,控制病情进展,改善骨代谢,减少脑电图棘波,以及保障患者用药安全,值得借鉴。Objective To investigate the effect of levetiracetam combined with sodium valproate on improving bone metabolism and reducing EEG spikes in adult patients with epilepsy.Methods The data of 78 adult epilepsy patients admitted to the Department of Neurology of Luohe Central Hospital from May 2019 to May 2020 were collected,and their treatment was reviewed.The clinical efficacy was compared between group A(n=39 cases)with sodium valproate alone and group B(n=39 cases)with levetiracetam and sodium valproate jointly.Results After two courses of treatment,the total effective rate of group B was 94.87%higher than that of group A(74.36%,P<0.05);The levels of type I collagen N-terminal propeptide and 25 hydroxyvitamin D_(3)in group B were higher than those in group A(P<0.05);EEG spikes in group B were less than those in group A(P<0.05);There was no significant difference in adverse reactions between the two groups(P>0.05).Conclusion The overall effect of levetiracetam combined with sodium valproate is ideal.It is worth using for reference to control the disease progress,improve bone metabolism,reduce EEG spikes,and ensure the drug safety of patients.
关 键 词:成人癫痫 左乙拉西坦 丙戊酸钠 骨代谢 脑电图棘波
分 类 号:R742.1[医药卫生—神经病学与精神病学]
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