基于真实世界研究中风合剂治疗急性缺血性脑卒中的临床研究  

Clinical Study of Zhongfeng Decoction Treatment for Acute Ischemic Stroke Based on Real-world Study

作　　者：古联[1] 宋潇宵 刘声莹 王洪海 王伟涛[2] Gu Lian;Song Xiaoxiao;Liu Shengying;Wang Honghai;Wang Weitao(The First Affiliated Hospital of Guangxi University of Chinese Medicine,Guangxi,Nanning 530023,China)

机构地区：[1]广西中医药大学第一附属医院,广西南宁530023 [2]广西中医药大学,广西南宁530001 [3]广西医科大学,广西南宁530021

出　　处：《中国中医急症》2024年第9期1557-1560,1576,共5页Journal of Emergency in Traditional Chinese Medicine

基　　金：国家自然科学基金项目(82160849);国家中医药管理局高水平中医药重点学科建设项目(zyyzdxk-2023167);国家中医药传承创新中心项目(发改办社会[2022]366号)。

摘　　要：目的基于真实世界临床数据观察中风合剂治疗急性缺血性脑卒中的临床疗效。方法采用回顾性研究方法,纳入急性缺血性脑卒中住院患者395例。根据患者是否服用中风合剂治疗,分为服用中风合剂的治疗组和未服用中风合剂的对照组,比较两组患者治疗前后美国国立卫生研究院卒中量表(NIHSS)评分变化,评估中风合剂治疗急性缺血性脑卒中的临床疗效。结果两组患者基线均衡可比(P>0.05)。治疗组治疗后NIHSS评分较治疗前下降(P<0.05)。治疗组有效率显著高于对照组,差异具有统计学意义(P<0.05)。在轻度、中度、重度神经功能缺损患者中,服用中风合剂的治疗组有效率均显著高于未服用中风合剂的对照组,差异具有统计学意义(均P<0.05)。亚组分析,男性患者中,治疗组有效率为47.00%,显著高于对照组的23.29%,差异有统计学意义(P<0.05);但是在女性患者中,有效率在两组之间的分布差异无统计学意义(P>0.05)。在合并高血压的缺血性脑卒中患者中,治疗组有效率(49.47%)显著高于对照组(23.19%),差异有统计学意义(P<0.05);在无合并高血压病患者中,治疗组与对照组有效率分布差异无统计学意义(P>0.05)。在合并糖尿病的缺血性脑卒中患者中,治疗组有效率(39.74%)显著高于对照组(15.38%),差异有统计学意义(P<0.05);无合并糖尿病的患者中,治疗组有效率(50.00%)亦显著高于对照组(28.40%),差异也有统计学意义(P<0.05)。结论真实世界临床实践中服用中风合剂能够有效改善急性缺血性脑卒中患者的神经功能缺损情况,提高临床疗效。Objective:To explore the clinical efficacy of Zhongfeng Decoction in the treatment of acute ischemic stroke based on real-world clinical data.Methods:A retrospective study method was employed,including 395 hospitalized patients with acute ischemic stroke.Patients were divided into a treatment group that received Zhongfeng Decoction and a control group that did not receive the decoction.The changes in the National Institutes of Health Stroke Scale(NIHSS)scores before and after treatment were compared between the two groups to evaluate the clinical efficacy of Zhongfeng Decoction in treating acute ischemic stroke.Results:Baseline characteristics were balanced and comparable between the two groups(P>0.05).After treatment,the NIHSS scores in the treatment group significantly decreased compared to before treatment(P<0.05).The effective rate in the treatment group was significantly higher than in the control group,with statistically significant differences(P<0.05).In patients with mild,moderate,and severe neurological deficits,the effective rate in the treatment group was significantly higher than in the control group,with statistically significant differences(all P<0.05).Subgroup analysis showed that in male patients,the effective rate in the treatment group(47.00%)was significantly higher than in the control group(23.29%),with statistically significant differences(P<0.05);however,there was no statistically significant difference in the distribution of effective rates between the two groups in female patients(P>0.05).In patients with ischemic stroke and comorbid hypertension,the effective rate in the treatment group(49.47%)was significantly higher than in the control group(23.19%),with statistically significant differences(P<0.05);however,there was no statistically significant difference in the distribution of effective rates between the two groups in patients without comorbid hypertension(P>0.05).In patients with ischemic stroke and comorbid diabetes,the effective rate in the treatment group(39.74%)was significantly

关 键 词：缺血性脑卒中 真实世界研究 中风合剂 美国国立卫生研究院卒中量表 

分 类 号：R743.9[医药卫生—神经病学与精神病学]