肝细胞癌组织中PLAGL2和SNX5的表达及临床预后价值研究  

Expressions and clinical prognostic significance of PLAGL2 and SNX5 in hepatocellular cancer tissue

作　　者：杨晓宏[1] 李鹏飞[1] 冯毅[1] 王璞 赵全胜 靳英 YANG Xiaohong;LI Pengfei;FENG Yi;WANG Pu;ZHAO Quansheng;JIN Ying(Department of General Surgery,Xinzhou Hospital Affiliated to Shanxi Medical University(Xinzhou People's Hospital),Xinzhou 034099,China;不详)

机构地区：[1]山西医科大学附属忻州医院(忻州市人民医院)普外科,034099 [2]山西医科大学附属忻州医院(忻州市人民医院)病理科,034099

出　　处：《浙江医学》2024年第17期1825-1829,1839,共6页Zhejiang Medical Journal

基　　金：山西省卫生健康委科研课题计划项目(2019052)。

摘　　要：目的探讨肝细胞癌(HCC)中多形性腺瘤基因样蛋白2(PLAGL2)和分拣微管连接蛋白5(SNX5)的表达及临床预后价值。方法回顾性选取2019年2月至2020年2月在山西医科大学附属忻州医院接受治疗的92例HCC患者为研究对象。采用免疫组化法检测HCC组织和癌旁组织中PLAGL2、SNX5表达情况。绘制Kaplan-Meier生存曲线,采用log-rank检验比较PLAGL2、SNX5阳性和阴性患者3年累积生存率。采用单因素和多因素Cox回归分析影响HCC预后的独立危险因素。结果HCC组织中PLAGL2和SNX5阳性率分别为78.26%(72/92)和76.09%(70/92),高于癌旁组织的6.52%(6/92)和4.35%(4/92),差异均有统计学意义(均P<0.01)。肿瘤最大径>5 cm、TNM分期Ⅲ期的患者PLAGL2和SNX5阳性率分别高于TNM分期Ⅰ~Ⅱ期、肿瘤最大径≤5 cm的患者,差异均有统计学意义(均P<0.05)。PPLAGL2阳性患者3年累积生存率为51.39%(37/72),低于PLAGL2阴性患者的80.00%(16/20),差异有统计学意义(P=0.037)。SNX5阳性患者3年累积生存率为50.00%(35/70),低于SNX5阴性患者的81.82%(18/22),差异有统计学意义(P=0.020)。肿瘤最大径>5 cm、TNM分期Ⅲ期、PLAGL2阳性及SNX5阳性均是影响HCC患者预后的独立危险因素(均P<0.01)。结论HCC组织中PLAGL2、SNX5阳性率升高,两者均参与促进HCC的发生、发展。PLAGL2阳性和SNX5阳性是影响HCC患者预后的独立危险因素,是HCC潜在的预后相关肿瘤标志物。Objective To investigate the expressions of pleomorphic adenoma gene like protein 2(PLAGL2)and sorting nexin 5(SNX5)in hepatocellular cancer(HCC)and their clinical prognostic significance.Methods Ninety-two HCC patients diagnosed and treated in Xinzhou Hospital Affiliated to Shanxi Medical University from February 2019 to February 2020 were enrolled in the study.Immunohistochemistry was used to detect the expressions of PLAGL2 and SNX5 in HCC tissue and adjacent tissue samples.Kaplan-Meier survival curve was drawn,and the 3-year cumulative survival of patients with postive and negative expressions of PLAGL2 and SNX5 was compared using log-rank test.Univariate and multivariate Cox regression analysis was used to analyze independent risk factors for HCC prognosis.Results The positive rates of PLAGL2 and SNX5 in HCC cancer tissue were 78.26%(72/92)and 76.09%(70/92),respectively,which were higher than those in adjacent tissues[6.52%(6/92)and 4.35%(4/92),both P<0.01].The positive rates of PLAGL2 and SNX5 in HCC patients with TNM stageⅢand maximum tumor diameter>5 cm were higher than those with TNM stagesⅠ-Ⅱand maximum tumor diameter≤5 cm(all P<0.05).The 3-year cumulative survival rate of the PLAGL2-positive patients was 51.39%(37/72),significantly lower than the 80.00%(16/20)of PLAGL2-negative patients(P=0.037).The 3-year cumulative survival rate of the SNX5-positive patients was 50.00%(35/70),also significantly lower than the 81.82%(18/22)of SNX5-negative patients(P=0.020).Maximum tumor diameter>5 cm,TNM stageⅢ,postive expressions of PLAGL2 and SNX5 were independent risk factors for prognosis of HCC patients(all P<0.01).Conclusion PLAGL2 and SNX5 positive rates increased in HCC tissues,both of which are involved in promoting the occurrence and development of HCC.Positive expressions of PLAGL2 and SNX5 are independent risk factors affecting the prognosis of HCC patients,and are potential prognostic tumor markers for HCC.

关 键 词：肝细胞癌 多形性腺瘤基因样蛋白2 分拣微管连接蛋白5 预后 

分 类 号：R735.7[医药卫生—肿瘤]