嗜酸性粒细胞性食管炎诊断及治疗进展  

Progress in diagnosis and treatment of eosinophilic esophagitis

作　　者：饶文辉 陈惠新[2] RAO Wenhui;CHEN Huixin(Guangdong Medical University the First Clinical Medicine College,Zhanjiang,Guangdong,524003,China;Huizhou Central People's Hospital,Huizhou,Guangdong,516000,China)

机构地区：[1]广东医科大学第一临床医学院,广东湛江524003 [2]惠州市中心人民医院消化内科,广东惠州516000

出　　处：《当代医学》2024年第14期188-194,共7页Contemporary Medicine

摘　　要：嗜酸性粒细胞食管炎(EoE)是由慢性免疫介导的食管炎症性疾病,其发病机制除与免疫介导相关外,还与遗传、环境及饮食习惯等因素相关,床上主要表现为食管功能障碍及食管黏膜存在大量嗜酸性粒细胞浸润。目前,EoE的治疗方式有饮食、药物及食管扩张治疗,又称“3D”治疗。EoE患者治疗的最终目标为提升患者生命质量,尽可能缓解临床症状及组织缓解,防止食管纤维化导致食管狭窄并发症发生。本文从流行病学、发病机制、临床表现、诊断和治疗等方面阐述EoE,加深对该病的认识、诊断及治疗。Eosinophilic esophagitis(EoE)is a chronic immune-mediated inflammatory disease of the esophagus,its pathogenesis is not only related to immune-mediated,but also related to genetic,environmental and dietary habits,clinically,the main symptoms are esophageal dysfunction and significant infiltration of eosinophils into the esophageal mucosa.At present,the treatment methods of EoE patients include diet therapy,drug therapy and esophageal dilatation therapy,also known as"3D"therapy.The ultimate goal of treatment for patients with EoE is to improve their quality of life,achieve clinical symptom relief and tissue relief as much as possible,and prevent the occurrence of esophageal stenosis complications caused by esophageal fibrosis.This article reviews the epidemiology,pathogenesis,clinical manifestations,diagnosis and treatment of Eosinophilic esophagitis in order to deepen the understanding of this disease and the prospect of diagnosis and treatment of eosinophilic esophagitis.

关 键 词：嗜酸性粒细胞性食管炎 饮食治疗 质子泵抑制剂 糖皮质激素 生物制剂 食管扩张 

分 类 号：R571[医药卫生—消化系统]