蜂毒研究进展:炎症性皮肤病治疗新型药物候选库  

Advances in bee venom research:novel drug candidate library for the treatment of inflammatory skin diseases

作　　者：吴强 杨悦 李鹏 顾佳婕 董德刚[2] 易军[2] WU Qiang;YANG Yue;LI Peng;GU Jiajie;DONG Degang;YI Jun(Nanchang Medical College,Nanchang 330052,China;Jiangxi University of Chinese Medicine,Nanchang 330004)

机构地区：[1]南昌医学院,南昌330052 [2]江西中医药大学,南昌330004

出　　处：《中国比较医学杂志》2024年第8期148-155,166,共9页Chinese Journal of Comparative Medicine

基　　金：国家自然科学基金(82260937);江西省中医药管理局科技计划(2023B0191)。

摘　　要：炎症性皮肤病(inflammatory skin disease,ISD)的特点是持续的炎症浸润和缠绵难愈的皮肤病变。皮质类固醇激素是目前治疗ISD的主要药物,但因ISD复发性与顽固性等特点,长期服用这些激素药物对患者产生较大副作用。近年来,越来越多研究证实,蜂毒具有显著的抗炎、抗凋亡、抗纤维化、抗菌与抗氧化等作用,从而有效治疗ISD。本文就蜂毒主要活性组分及其抗炎机制,及蜂毒治疗包括痤疮、特应性皮炎、银屑病、过敏性接触性皮炎等ISD的新进展进行综述,为ISD的基础研究与临床治疗提供借鉴与参考。Inflammatory skin diseases(ISD)are characterized by persistent inflammatory cell infiltration and lingering and intractable skin lesions.At present,corticosteroids are the main drugs used in the treatment of ISD.However,due to the characteristics of recurrent and intractable ISD,long-term use of these hormone drugs may cause serious side effects in patients.In recent years,increasingly more studies are confirming that bee venom has significant anti-inflammatory,anti-apoptosis,anti-fibrosis,antibacterial,and other effects and could effectively treat ISD.In this paper,the main active components and anti-inflammatory mechanisms of bee venom are reviewed.The latest attempts to use bee venom for acne,atopic dermatitis,psoriasis,urticaria,and systemic lupus erythematosus are discussed,providing a reference for basic research and the clinical treatment of ISD.

关 键 词：蜂毒 活性成分 炎症性皮肤病 机制 

分 类 号：R-33[医药卫生]