基于中西医临床病证特点的银屑病性关节炎动物模型分析  

Analysis of animal model of psoriatic arthritis based on Chinese and Western medicine characteristics

作　　者：史亚瑾 李寒冰[1] 李根林[1] 吴宿慧[1] SHI Yajin;LI Hanbing;LI Genlin;WU Suhui(Henan University of Chinese medicine,Henan Health Aging Industry Engineering Research Center,Zhengzhou 450046,China)

机构地区：[1]河南中医药大学,河南省健康衰老产业工程研究中心,郑州450046

出　　处：《中国比较医学杂志》2024年第8期156-166,共11页Chinese Journal of Comparative Medicine

基　　金：国家重点研发计划项目(2020YFE0201800);河南省中医药科学研究专项(20-21ZY1041);河南省科技攻关项目(232102311191)。

摘　　要：近年来,随着银屑病性关节炎在我国的发病率逐渐升高且其无法治愈,已经成为了医学事业上的一大难题。本研究基于中西医临床病证特点,积极探讨银屑病性关节炎的发病病机,总结目前现有的动物模型并进行分析评价。对当前所查询到符合本题的文献进行整理归纳总结,通过银屑病性关节炎的中西医病因病机研究、中西医的诊断标准和动物模型的特点及与临床吻合度的分析,给予现有动物模型吻合度评分。本论述发现人白细胞抗原转基因鼠模型、多重杂交转基因小鼠模型以及甘露聚糖诱导的小鼠模型吻合度评分最高。由于银屑病性关节炎多见于欧洲,目前动物模型的制备方法多由国外传来,中医病证特点制备的动物模型极少,因此,西医诊断的模型吻合度评分整体高于中医诊断的吻合度评分。希望未来可以结合中医的独特诊疗方法,进一步完善银屑病性关节炎的动物模型种类,为中西医结合治疗银屑病性关节炎构建更理想的动物模型提供基础。In recent years,psoriatic arthritis has become a major problem in the medical field,with cases gradually increasing in China,and it is still incurable.Here,we summarize the pathogenesis and clinical characteristics of currently available animal models of psoriatic arthritis based on Chinese and Western medical evidence.Literature in line with this topic was collated and summarized.The etiology and pathogenesis according to Chinese and Western medicine of existing psoriatic arthritis models were given agreement scores;the diagnostic criteria of Chinese and Western medicine were compared;and the models’characteristics and degree of agreement with clinical observations were assessed.This study found that the human leukocyte antigen transgenic mouse model,the multiple hybridization transgenic mouse model,and the mannan-induced mouse model had the highest agreement scores.As psoriatic arthritis is more common in Europe,Methods for the preparation of animal models have been mostly imported from abroad,and very few animal models have the characteristics of Chinese medicine;therefore,the model fitness scores of Western diagnoses were higher than those of Chinese diagnoses as a whole.We hope to leverage the unique diagnosis and treatment method of Chinese medicine further to improve the types of psoriatic arthritis animal models available.This study provides a basis for the construction of improved animal models of psoriatic arthritis with combined traditional Chinese and Western medicine characteristics.

关 键 词：银屑病性关节炎 临床病证特点 动物模型 吻合度 

分 类 号：R-33[医药卫生]