神经免疫炎症交互作用在中医药治疗抑郁症中的研究进展  

Research development on the interaction between neuroimmunity and inflammation in the treatment of depressive disorder by traditional Chinese medicine

作　　者：郭冬静 潘文超 王思嘉 毛前程 张洪秀 马柯 GUO Dongjing;PAN Wenchao;WANG Sijia;MAO Qiancheng;ZHAGN Hongxiu;MA Ke(Shandong University of Traditional Chinese Medicine,Institute of Traditional Chinese Medicine,Jinan 250355,China;Center for Disease Control and Prevention,Jinan 250021;Shandong University of Traditional Chinese Medicine,First Clinical Medical College,Jinan 250014;Third Affiliated Hospital,Beijing University of Chinese Medicine,Beijing 100029)

机构地区：[1]山东中医药大学中医学院,济南250355 [2]济南市疾病预防与控制中心,济南250021 [3]山东中医药大学第一临床医学院,济南250014 [4]北京中医药大学第三附属医院,北京100029

出　　处：《中国比较医学杂志》2024年第8期167-177,共11页Chinese Journal of Comparative Medicine

基　　金：山东省自然科学基金(ZR2023QH052);山东省高校青创人才引育计划(鲁教人字[2019]9号-202);山东省中医药高层次人才培育项目专项经费(卫函[2023]14号);上海科技发展基金会专项基金科研项目(2013-701627);国家自然科学基金(81903948)。

摘　　要：抑郁症作为常见的心境障碍,发病机制复杂,近年来随着人们生活节奏的加快,患病率逐年攀升,引起人们的广泛关注。外界应激和炎症共同损害血管和脑区功能,诱发免疫失调,引起小胶质细胞活化和促炎性细胞因子及其受体表达增加,炎症反应持续发生,影响神经递质系统的正常代谢和分子通路的正常运行,导致脑细胞和神经异变,进一步形成的免疫-炎症-神经循环路径成为抑郁症发生发展的重要机制。大量研究表明中医药治疗可以通过恢复神经免疫炎症稳态改善抑郁症状,本文从神经免疫炎症角度出发,阐述其与抑郁症及其发病机制的密切联系,并对多种中医疗法通过调节神经免疫炎症改善和治疗抑郁症的作用进行综述,以期为抑郁症的精准治疗以及中医药免疫靶向药物研发提供新视角。Depression,a common mood disorder,has a complex pathogenesis.In recent years,the accelerated pace of life has been accompanied by an increase in the prevalence rate of depression,leading to extensive attention being given to this condition.External stress and inflammation synergize to damage blood vessel and brain functions,induce immune disorders,cause microglia activation,and increase the expression of pro-inflammatory cytokines and their receptors.Inflammatory reactions continue to escalate,which affects the normal metabolism and metabolism of the neurotransmitter system.The abnormal functioning of molecular pathways leads to mutations in brain cell and nerve genes,and further formation of the immune-inflammation-neuron cycle pathway becomes an important mechanism in the occurrence and development of depression.A large number of studies have shown that traditional Chinese medicines can improve depression symptoms by restoring neuroimmune inflammation homeostasis.This article explains neuroimmune inflammation’s close connection with depression and its pathogenesis and reviews the role of various traditional Chinese medical therapies in improving and treating depression by participating in the regulation of neuroimmune inflammation.This review provides new perspectives on the precise treatment of depression and the development of immune-targeted drugs.

关 键 词：抑郁症 神经免疫炎症 中医药 交互作用 

分 类 号：R-33[医药卫生]