慢性胰腺炎继发良性胆道狭窄治疗进展  

Advances in the therapy for benign biliary stricture secondary to chronic pancreatitis

作　　者：郭芮希 刘雨 王丹 胡良皞 GUO Rui-xi;LIU Yu;WANG Dan;HU Liang-hao(College of Basic Medical Sciences,Naval Medical University,Shanghai 200433,China;不详)

机构地区：[1]海军军医大学基础医学院,上海200433 [2]海军军医大学第一附属医院消化内科,上海200433 [3]中国人民解放军东部战区总医院消化内科,江苏南京210002

出　　处：《中国实用内科杂志》2024年第7期553-556,566,共5页Chinese Journal of Practical Internal Medicine

基　　金：国家自然科学基金(82200723);73批中国博士后科学基金(2023M734266)。

摘　　要：良性胆道狭窄是慢性胰腺炎的常见并发症,其治疗旨在缓解胆道梗阻症状,维持长期通畅引流。当胆道狭窄伴上游胆管扩张,出现黄疸、胆管炎、胆总管结石等并发症,或无明显症状下存在血清碱性磷酸酶升高(>正常值上限的2~3倍)和(或)胆红素升高1个月时,需行内镜治疗或外科手术治疗。近年来随着新兴技术的不断涌现,胆管内射频消融等新技术有望为患者提供新的选择。文章就慢性胰腺炎继发良性胆道狭窄的治疗进展进行综述,以期为临床诊治提供参考。Benign biliary stricture(BBS)is a prevalent complication of chronic pancreatitis(CP),with treatment strategies primarily focused on alleviating symptoms of biliary obstruction andmaintaining long-term unobstructed drainage.Endoscopic or surgical treatment is indicated when a biliary stricture is associated with upstream bile duct dilation,complications such as jaundice,cholangitis,and choledocholithiasis occur,or when serum alkaline phosphatase levels are elevated(>2-3 times the upper limit of normal)and(or)bilirubin levels are elevated for 1 month withoutobvious symptoms.In recent years,with the continuous emergence of new technologies,newtechnologies such as intrabile duct radiofrequency ablation are expected to provide new optionsfor patients.This article reviews the progress in treating benign biliary stricture secondary tochronic pancreatitis to provide a reference for clinical diagnosis and treatment.

关 键 词：慢性胰腺炎 良性胆道狭窄 经内镜逆行胰胆管造影 胆管内射频消融 外科手术 

分 类 号：R576[医药卫生—消化系统]