母乳维生素D水平及影响因素的系统综述  

THE LEVEL OF VITAMIN D IN BREAST MILK AND ITS INFLUENCING FACTORS:A SYSTEMATIC REVIEW

作　　者：那晓娜 于昊冉 赖建强 汪之顼[7] 张环美[4,5,6] 赵艾 NA Xiao-na;YU Hao-ran;LAI Jian-qiang;WANG Zhi-xu;ZHANG Huan-mei;ZHAO Ai(Vanke School of Public Health,Tsinghua University,Beijing 100084;Institute for Healthy China,Tsinghua University,Beijing 100084;School of Public Health,Southern Medical University,Guangzhou 510515;National Institute for Nutrition and Health,Chinese Center for Disease Control and Prevention,Beijing 100050;China-DRIs Research Group on Human Milk Composition,Beijing 100050;Key Laboratory of Human Milk Science,Chinese Center for Disease Control and Prevention,Beijing 100050;School of Public Health,Nanjing Medical University,Nanjing 211166)

机构地区：[1]清华大学万科公共卫生与健康学院,北京100084 [2]清华大学健康中国研究院,北京100084 [3]南方医科大学公共卫生学院,广州510515 [4]中国疾病预防控制中心营养与健康所,北京100050 [5]中国DRIs母乳成分研究工作组,北京100050 [6]中国疾病预防控制中心母乳科学研究重点实验室,北京100050 [7]南京医科大学公共卫生学院,南京211166

出　　处：《营养学报》2024年第3期302-308,共7页Acta Nutrimenta Sinica

摘　　要：目的综述母乳维生素D水平,为婴儿补充维生素D提供参考。方法系统检索CNKI、万方、维普、中国生物医学文献数据库、PubMed、WebofScience、Embase、Cochranelibrary中英文数据库,收集2022年4月之前公开发表的母乳维生素D水平的相关文献。将维生素D质量单位统一后,根据均数和标准差合并公式,计算国内外不同亚组母乳维生素D含量。结果最终纳入14篇报告了足月分娩健康母亲母乳维生素D含量的原始文献,其中中国人群3篇,国外人群11篇。结果显示,中国足月分娩健康母亲初乳、过渡乳、成熟乳中维生素D含量(μg/L)分别为(0.801±0.342)、(25.132±30.540)、(3.792±0.614)。国外足月分娩健康母亲初乳、过渡乳、成熟乳中维生素D含量(μg/L)分别为(25.191±15.845)、(1.045±1.740)、(0.943±2.034)。结论国内外母乳维生素D水平差异较大,且受多种因素影响。未来需要更大样本量的研究,了解母乳维生素D含量及影响因素。Objective To assess the level of vitamin D in breast milk and provide evidence for vitamin D supplementation in the infants.Methods We searched for relevant studies published up to April 2022 from CNKI,Wanfang,VIP,CB-Mdisc,PubMed,Web of Science,Embase,and Cochrane library.After unifying the unit of vitamin D,we calculated the level of vitamin D in breast milk among the participants in different subgroups in China and abroad according to statistical formulas.Results A total of 14 articles were included in this study,including 3 articles performed in China and 11 articles performed in other countries.Our study showed that the levels of vitamin D in breast milk among Chinese healthy mothers with term infants in colostrum,transitional,and mature milk were(0.801±0.342)μg/L,(25.132±30.540)μg/L,and(3.792±0.614)μg/L,respectively.The levels of vitamin D in breast milk among foreign healthy mothers with term infants in colostrum,transitional,and mature milk were(25.191±15.845)μg/L,(1.045±1.740)μg/L,and(0.943±2.034)μg/L,respectively.Conclusion The level of vitamin D in breast milk in China was very different from that in other countries,which was influenced by numerous factors.Studies with larger sample sizes are needed to investigate the level of vitamin D in breast milk and its influencing factors.

关 键 词：母乳 维生素D 水平 泌乳阶段 

分 类 号：R153.1[医药卫生—营养与食品卫生学]