长链非编码RNA参与调控肿瘤中髓源性抑制细胞的研究进展  

Research advance on long non⁃coding RNA regulating myeloid⁃derived suppressor cells in tumors

作　　者：罗铿军 张文波[1] 蒋鹏程[1] LUO Kengjun;ZHANG Wenbo;JIANG Pengcheng(Department of General Surgery,People′s Hospital Affiliated to Jiangsu University,Zhenjiang 212002,China)

机构地区：[1]江苏大学附属人民医院普外科,江苏镇江212002

出　　处：《实用医学杂志》2024年第18期2647-2653,共7页The Journal of Practical Medicine

基　　金：国家自然科学基金青年基金面上项目(编号:81500193,81802409);中国博士后科学基金项目(编号:2015M571703);江苏省卫生健康委医学科研面上项目(编号:M2022100,M2022117);江苏省自然科学基金面上项目(编号:BK20231250);镇江市重点研发计划社会发展面上项目(编号:SH2021035,SH2021036);江苏大学医教协同创新基金一般项目(编号:JDYY2023022)。

摘　　要：长链非编码RNA(long non-coding RNA,lncRNA)作为一组长度超过200 nt的非编码RNA,其在人类转录组中占据重要地位,且在多种癌症类型中发挥着重要作用,尤其是在调节肿瘤免疫微环境和肿瘤细胞免疫逃逸方面具有关键作用,但目前尚缺乏较为系统的文献总结。髓源性抑制细胞(myeloidderived suppressor cells,MDSCs)作为一类具有免疫抑制作用的髓系细胞,在肿瘤中扮演着重要角色,通过直接和间接抑制T细胞的活性、促进调节性T细胞的扩增、调节肿瘤微环境、促进肿瘤转移等方式,影响着肿瘤的生长、免疫抑制和转移。该文强调了对MDSCs调控机制的深入研究对于发现有效的肿瘤治疗靶点和开发新的治疗策略具有重要意义。随着对lncRNA与MDSCs关系的进一步认识和研究,有望为肿瘤治疗提供更多的靶点和新的治疗方法,以改善患者的临床结局。Long non-coding RNAs(lncRNAs),a group of non-coding RNAs with lengths exceeding 200 nucleotides,play a crucial role in the human transcriptome,particularly in various types of cancers,where they are pivotal in regulating the tumor immune microenvironment and tumor cell immune evasion.However,there is currently a lack of systematic literature review.Myeloid-derived suppressor cells(MDSCs),a subset of myeloid cells with immunosuppressive functions,play a significant role in cancer by directly and indirectly suppressing T cell activity,promoting the expansion of regulatory T cells,modulating the tumor microenvironment,and facilitating tumor metastasis.This review emphasizes the importance of in-depth investigation into the regulatory mechanisms of MDSCs for the discovery of effective tumor therapeutic targets and the development of novel treatment strategies.With further understanding and research into the relationship between lncRNAs and MDSCs,it is anticipated that more targets and new therapeutic approaches will be identified for cancer treatment,thereby improving clinical outcomes for patients.

关 键 词：长链非编码RNA 髓源性抑制细胞 肿瘤 肿瘤微环境 肿瘤免疫 

分 类 号：R735.2[医药卫生—肿瘤]