肿瘤放疗患者疲劳状况变化影响因素分析  

Analysis on influencing factors in fatigue status changes in patients with tumor radiotherapy

作　　者：王斐然 陈虹宇 庞得全 WANG Feiran;CHEN Hongyu;PANG Dequan(Department of Radiotherapy,Affiliated Hospital of North China University of Science and Technology,Tangshan,Hebei 063000,China)

机构地区：[1]华北理工大学附属医院放疗科,河北唐山063000

出　　处：《重庆医学》2024年第18期2730-2734,共5页Chongqing Medical Journal

基　　金：河北省重点医学科学研究课题(20240574)。

摘　　要：目的探讨肿瘤患者放疗前后疲劳状况变化及其影响因素。方法选取2023年2-9月在该院放疗科进行放射治疗的150例肿瘤患者为研究对象,采用一般资料问卷和多维疲劳量表(MFI-20)进行调查,比较放疗前后疲劳得分和自主神经功能变化情况,多因素logistic回归分析疲劳状况变化的影响因素。结果与放疗前比较,放疗后平均疲劳得分更高[(63.99±14.54)分vs.(52.75±17.18)分],低频(LF)、高频(HF)、总功率(TP)、时域指标窦性心搏RR间期标准差(SDNN)、相邻NN间期之差的均方根值(rMSSD)更低,LF/HF更高,差异有统计学意义(P<0.05)。单因素分析结果显示,不同临床分期、慢性病史、疼痛评分、血红蛋白、淋巴细胞、WBC、心率变异性(HRV)患者的疲劳情况比较,差异有统计学意义(P<0.05)。多因素logistic分析结果显示,血红蛋白、WBC、HRV降低是导致疲劳加重的独立危险因素(P<0.05)。结论应指导临床对疲劳加重的影响因素进行干预以改善肿瘤患者结局。Objective To explore the changes of fatigue status before and after radiotherapy in tumor patients and its influencing factors.Methods A total of 150 tumor patients with radiotherapy in the radiotherapy department of this hospital from February to September 2023 were selected as the study subjects.The general data questionnaire and the Multidimensional Fatigue Scale(MFI-20)were adopted to conduct the survey.The fatigue scores and the changes in autonomic nervous function were compared between before and after radiotherapy.The multifactor logistic regression was applied to analyze the influencing factors of changes in fatigue status.Results Compared with before radiotherapy,the average fatigue scores after radiotherapy were higher[(63.99±14.54)points vs.(52.75±17.18)points],low frequency(LF),and high frequency(HF),total power(TP),time domain indicators sinus heart beat RR interval standard deviation(SDNN)and the root-mean-square value of the difference between adjacent NN interval(rMSSD)were lower,LF/HF was higher,and the differences were statistically significant(P<0.05).The univariate analysis results showed that the fatigue situation had statistical difference among the patients with different clinical stages,chronic disease history,pain scores,hemoglobin,lymphocyte,WBC and heart rate variability(HRV,P<0.05).The multivariate logistic regression analysis results showed that the decrease of hemoglobin,WBC and HRV were the independent risk factors of fatigue aggravation(P<0.05).Conclusion It is necessary to guide the clinic to conduct the intervention on the influencing factors aggravating fatigue to improve the outcome of the patients with tumor.

关 键 词：肿瘤放射治疗 疲劳得分 心率变异性 自主神经病变 影响因素 

分 类 号：R730.55[医药卫生—肿瘤]