银杏叶提取物注射液联合尤瑞克林治疗急性脑梗死患者的效果  

Effects of Ginkgo biloba extract injection combined with Urinary kallindinogenase in treatment of patients with acute cerebral infarction

作　　者：高云峰 张亮 GAO Yunfeng;ZHANG Liang(Department of Neurology of Zhenping County Second People’s Hospital,Nanyang 474250 Henan,China)

机构地区：[1]镇平县第二人民医院神经内科,河南南阳474250

出　　处：《中国民康医学》2024年第19期92-95,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察银杏叶提取物注射液联合尤瑞克林治疗急性脑梗死患者的效果。方法:选取2022年8月至2023年8月该院收治的156例急性脑梗死患者进行前瞻性研究,按照随机数字表法将其分为研究组和对照组各78例。两组均予以常规治疗,在此基础上,对照组采用尤瑞克林治疗,研究组在对照组基础上联合银杏叶提取物注射液治疗,两组均连续治疗8周。比较两组临床疗效,治疗前后神经功能[改良Rankin量表(MRS)、美国国立卫生研究院卒中量表(NIHSS)]评分、血液流变学指标[血浆黏度(PV)、纤维蛋白原(FIB)、全血低切黏度(LBV)]水平、血管内皮功能指标[内皮素-1(ET-1)、同型半胱氨酸(Hcy)、一氧化氮(NO)]水平,以及不良反应发生率。结果:研究组治疗总有效率为93.59%(73/78),高于对照组的83.33%(65/78),差异有统计学意义(P<0.05);治疗后,研究组NIHSS、MRS评分均低于对照组,差异有统计学意义(P<0.05);治疗后,研究组PV、FIB、LBV水平均低于对照组,差异有统计学意义(P<0.05);治疗后,研究组NO水平高于对照组,ET-1、Hcy水平低于对照组,差异均有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:银杏叶提取物注射液联合尤瑞克林治疗急性脑梗死患者可提高治疗总有效率,降低神经功能评分、血液流变学指标水平,改善血管内皮功能指标水平,效果优于单纯尤瑞克林治疗。Objective:To observe effects of Ginkgo biloba extract injection combined with Urinary kallindinogenase in treatment of patients with acute cerebral infarction.Methods:A prospective study was conducted on 156 patients with acute cerebral infarction admitted to this hospital from August 2022 to August 2023.According to the random number table method,they were divided into study group and control group,78 cases in each group.Both groups were given routine treatment.On this basis,the control group was treated with Urinary kallindinogenase,while the study group was treated with Ginkgo biloba extract injection on the basis of that of the control group.Both groups were treated for 8 weeks.The clinical efficacy,the neurological function[modified Rankin scale(MRS),National Institutes of Health stroke scale(NIHSS)]score,the hemorheology indexes[plasma viscosity(PV),fibrinogen(FIB),whole blood low shear viscosity(LBV)]levels,and vascular endothelial function indexes[endothelin-1(ET-1),homocysteine(Hcy),nitric oxide(NO)]levels before and after the treatment,and the incidence of adverse reactions were compared.Results:The total effective rate of the study group was 93.59%(73/78),which was higher than 83.33%(65/78)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the NIHSS and MRS scores of the study group were lower than those of the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of PV,FIB and LBV in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the level of NO in the study group was higher than that in the control group,the levels of ET-1 and Hcy were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Ginkgo biloba extract injection combined with Urinary kallindin

关 键 词：银杏叶提取物注射液 尤瑞克林 急性脑梗死 神经功能 脑血液流变学 血管内皮功能 

分 类 号：R743.3[医药卫生—神经病学与精神病学]